Factors Affecting Extracellular Vesicles Based Drug Delivery Systems
Extracellular vesicles (EVs) play major roles in intracellular communication and participate in several biological functions in both normal and pathological conditions. Surface modification of EVs via various ligands, such as proteins, peptides, or aptamers, offers great potential as a means to achi...
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2021-03-01
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doaj-2edc89dfa892422886efd215431562202021-03-12T00:04:39ZengMDPI AGMolecules1420-30492021-03-01261544154410.3390/molecules26061544Factors Affecting Extracellular Vesicles Based Drug Delivery SystemsIsha Gaurav0Abhimanyu Thakur1Ashok Iyaswamy2Xuehan Wang3Xiaoyu Chen4Zhijun Yang5School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaCentre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation-CAS Limited, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaExtracellular vesicles (EVs) play major roles in intracellular communication and participate in several biological functions in both normal and pathological conditions. Surface modification of EVs via various ligands, such as proteins, peptides, or aptamers, offers great potential as a means to achieve targeted delivery of therapeutic cargo, i.e., in drug delivery systems (DDS). This review summarizes recent studies pertaining to the development of EV-based DDS and its advantages compared to conventional nano drug delivery systems (NDDS). First, we compare liposomes and exosomes in terms of their distinct benefits in DDS. Second, we analyze what to consider for achieving better isolation, yield, and characterization of EVs for DDS. Third, we summarize different methods for the modification of surface of EVs, followed by discussion about different origins of EVs and their role in developing DDS. Next, several major methods for encapsulating therapeutic cargos in EVs have been summarized. Finally, we discuss key challenges and pose important open questions which warrant further investigation to develop more effective EV-based DDS.https://www.mdpi.com/1420-3049/26/6/1544extracellular vesiclesexosomesdrug delivery systemstargeted delivery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isha Gaurav Abhimanyu Thakur Ashok Iyaswamy Xuehan Wang Xiaoyu Chen Zhijun Yang |
spellingShingle |
Isha Gaurav Abhimanyu Thakur Ashok Iyaswamy Xuehan Wang Xiaoyu Chen Zhijun Yang Factors Affecting Extracellular Vesicles Based Drug Delivery Systems Molecules extracellular vesicles exosomes drug delivery systems targeted delivery |
author_facet |
Isha Gaurav Abhimanyu Thakur Ashok Iyaswamy Xuehan Wang Xiaoyu Chen Zhijun Yang |
author_sort |
Isha Gaurav |
title |
Factors Affecting Extracellular Vesicles Based Drug Delivery Systems |
title_short |
Factors Affecting Extracellular Vesicles Based Drug Delivery Systems |
title_full |
Factors Affecting Extracellular Vesicles Based Drug Delivery Systems |
title_fullStr |
Factors Affecting Extracellular Vesicles Based Drug Delivery Systems |
title_full_unstemmed |
Factors Affecting Extracellular Vesicles Based Drug Delivery Systems |
title_sort |
factors affecting extracellular vesicles based drug delivery systems |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-03-01 |
description |
Extracellular vesicles (EVs) play major roles in intracellular communication and participate in several biological functions in both normal and pathological conditions. Surface modification of EVs via various ligands, such as proteins, peptides, or aptamers, offers great potential as a means to achieve targeted delivery of therapeutic cargo, i.e., in drug delivery systems (DDS). This review summarizes recent studies pertaining to the development of EV-based DDS and its advantages compared to conventional nano drug delivery systems (NDDS). First, we compare liposomes and exosomes in terms of their distinct benefits in DDS. Second, we analyze what to consider for achieving better isolation, yield, and characterization of EVs for DDS. Third, we summarize different methods for the modification of surface of EVs, followed by discussion about different origins of EVs and their role in developing DDS. Next, several major methods for encapsulating therapeutic cargos in EVs have been summarized. Finally, we discuss key challenges and pose important open questions which warrant further investigation to develop more effective EV-based DDS. |
topic |
extracellular vesicles exosomes drug delivery systems targeted delivery |
url |
https://www.mdpi.com/1420-3049/26/6/1544 |
work_keys_str_mv |
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1724223361395982336 |