MLL becomes functional through intra-molecular interaction not by proteolytic processing.

MLL becomes functional through intra-molecular interaction not by proteolytic processing.

The mixed lineage leukemia (MLL) protein is an epigenetic transcriptional regulator that controls proliferative expansion of immature hematopoietic progenitors, whose aberrant activation triggers leukemogenesis. A mature MLL protein is produced by formation of an intra-molecular complex and proteoly...

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Bibliographic Details
Main Authors: Akihiko Yokoyama, Francesca Ficara, Mark J Murphy, Christian Meisel, Chikako Hatanaka, Issay Kitabayashi, Michael L Cleary
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3769346?pdf=render

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