Less circulating mucosal-associated invariant T cells in patients with cervical cancer

Objective: Mucosal-associated invariant T cells (MAITs) are important for immune defense against infectious pathogens and regulation of various inflammatory diseases. However, their roles in cancer are rarely reported. Since cervical cancer is one of the diseases involving mucosal tissue, we try to...

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Main Authors: Wan-Chun Huang, Yu-Chia Hsiao, Chao-Chih Wu, Yun-Ting Hsu, Chih-Long Chang
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Taiwanese Journal of Obstetrics & Gynecology
Online Access:http://www.sciencedirect.com/science/article/pii/S1028455918302961
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spelling doaj-2ee701ac58a64a15be74ec3a866f7a022020-11-25T00:51:48ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592019-01-01581117121Less circulating mucosal-associated invariant T cells in patients with cervical cancerWan-Chun Huang0Yu-Chia Hsiao1Chao-Chih Wu2Yun-Ting Hsu3Chih-Long Chang4Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medical Research, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medical Research, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medical Research, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Corresponding author. Department of Obstetrics and Gynecology, MacKay Memorial Hospital, No. 92, Section 2, Chung-Shan North Road, 104, Taipei, Taiwan. Fax: +886 2 25433642.Objective: Mucosal-associated invariant T cells (MAITs) are important for immune defense against infectious pathogens and regulation of various inflammatory diseases. However, their roles in cancer are rarely reported. Since cervical cancer is one of the diseases involving mucosal tissue, we try to investigate the association between circulating MAITs and cervical cancer. Materials and methods: Blood samples were obtained from patients with cervical cancer (n = 47) and healthy individuals (n = 39). We determined phenotypic MAITs in peripheral blood mononuclear cells (PBMCs) and evaluated the percentage of MAITs in CD3+ cells by flow cytometry. The percentage of MAITs was stratified according to Federation of Gynecology and Obstetrics (FIGO) staging system in patients with cervical cancer. Progression-free survival (PFS) with respect to the amount of MAITs was also analyzed. Results: The percentage of circulating MAITs in patients with cervical cancer was significantly lower than in healthy group (0.987% vs. 4.008%, p < 0.0001). In subgroup analysis, though not statistically significant, it showed a trend of lower percentage of circulating MAITs in cervical cancer patients with FIGO stage II-IV disease than in patients with FIGO stage I disease (0.4045% vs. 1.098%, p = 0.11). A trend of poor PFS in patients with lower circulating MAITs was also noted. Conclusion: MAITs play a crucial role in cancer immunity. The decrease of MAITs in peripheral blood is related to cervical cancer. There is a trend of lower percentage of MAITs in advanced stages and lower percentage of MAITs towards poor PFS in patients with cervical cancer. Keywords: Cervical cancer, MAIT, mucosal-associated invariant T cell, Immune, Progression-free survivalhttp://www.sciencedirect.com/science/article/pii/S1028455918302961
collection DOAJ
language English
format Article
sources DOAJ
author Wan-Chun Huang
Yu-Chia Hsiao
Chao-Chih Wu
Yun-Ting Hsu
Chih-Long Chang
spellingShingle Wan-Chun Huang
Yu-Chia Hsiao
Chao-Chih Wu
Yun-Ting Hsu
Chih-Long Chang
Less circulating mucosal-associated invariant T cells in patients with cervical cancer
Taiwanese Journal of Obstetrics & Gynecology
author_facet Wan-Chun Huang
Yu-Chia Hsiao
Chao-Chih Wu
Yun-Ting Hsu
Chih-Long Chang
author_sort Wan-Chun Huang
title Less circulating mucosal-associated invariant T cells in patients with cervical cancer
title_short Less circulating mucosal-associated invariant T cells in patients with cervical cancer
title_full Less circulating mucosal-associated invariant T cells in patients with cervical cancer
title_fullStr Less circulating mucosal-associated invariant T cells in patients with cervical cancer
title_full_unstemmed Less circulating mucosal-associated invariant T cells in patients with cervical cancer
title_sort less circulating mucosal-associated invariant t cells in patients with cervical cancer
publisher Elsevier
series Taiwanese Journal of Obstetrics & Gynecology
issn 1028-4559
publishDate 2019-01-01
description Objective: Mucosal-associated invariant T cells (MAITs) are important for immune defense against infectious pathogens and regulation of various inflammatory diseases. However, their roles in cancer are rarely reported. Since cervical cancer is one of the diseases involving mucosal tissue, we try to investigate the association between circulating MAITs and cervical cancer. Materials and methods: Blood samples were obtained from patients with cervical cancer (n = 47) and healthy individuals (n = 39). We determined phenotypic MAITs in peripheral blood mononuclear cells (PBMCs) and evaluated the percentage of MAITs in CD3+ cells by flow cytometry. The percentage of MAITs was stratified according to Federation of Gynecology and Obstetrics (FIGO) staging system in patients with cervical cancer. Progression-free survival (PFS) with respect to the amount of MAITs was also analyzed. Results: The percentage of circulating MAITs in patients with cervical cancer was significantly lower than in healthy group (0.987% vs. 4.008%, p < 0.0001). In subgroup analysis, though not statistically significant, it showed a trend of lower percentage of circulating MAITs in cervical cancer patients with FIGO stage II-IV disease than in patients with FIGO stage I disease (0.4045% vs. 1.098%, p = 0.11). A trend of poor PFS in patients with lower circulating MAITs was also noted. Conclusion: MAITs play a crucial role in cancer immunity. The decrease of MAITs in peripheral blood is related to cervical cancer. There is a trend of lower percentage of MAITs in advanced stages and lower percentage of MAITs towards poor PFS in patients with cervical cancer. Keywords: Cervical cancer, MAIT, mucosal-associated invariant T cell, Immune, Progression-free survival
url http://www.sciencedirect.com/science/article/pii/S1028455918302961
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