Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic rats
<p>Abstract</p> <p>Background</p> <p>Rose-scented geranium (<it>Pelargonium graveolens</it> L’Hér.), which is used in traditional Tunisian folk medicine for the treatment of hyperglycaemia, is widely known as one of the medicinal herbs with the highest antio...
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doaj-2f0b80e85ced40fe8f42d35534015dff2020-11-24T23:16:15ZengBMCLipids in Health and Disease1476-511X2012-06-011118110.1186/1476-511X-11-81Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic ratsBoukhris MaherBouaziz MohamedFeki InesJemai HedyaEl Feki AbdelfattahSayadi Sami<p>Abstract</p> <p>Background</p> <p>Rose-scented geranium (<it>Pelargonium graveolens</it> L’Hér.), which is used in traditional Tunisian folk medicine for the treatment of hyperglycaemia, is widely known as one of the medicinal herbs with the highest antioxidant activity. The present paper is conducted to test the hypoglycemic and antioxidative activities of the leaf essential oil of <it>P. graveolens</it>.</p> <p>Methods</p> <p>The essential oil <it>P. graveolens</it> was administered daily and orally to the rats at two doses of 75 mg/kg and 150 mg/kg body weight (b.w.) for 30 days. The chemical composition of <it>P. graveolens</it> essential oil, body weight, serum glucose, hepatic glycogen, thiobarbituric acid-reactive substances (TBARS), the components of hepatic, and renal and serum antioxidant systems were evaluated. The hypoglycemic effect of rose-scented geranium was compared to that of the known anti-diabetic drug glibenclamide (600 μg/kg b.w.).</p> <p>Results</p> <p>After the administration of two doses of essential oil of <it>Pelargonium graveolens</it> L’Hér. together with glibenclamide which is known by its antidiabetic activities and used as reference (600 μg/kg b.w.), for four weeks, the serum glucose significantly decreased and antioxidant perturbations were restored. The hypoglycemic effect of <it>P. graveolens</it> at the dose of 150 mg/kg b.w. was significantly (<it>p</it>< 0.05) more effective than that of glibenclamide. It is through the histological findings in hepatic and renal tissues of diabetic rats that these beneficial effects of geranium oils were confirmed.</p> <p>Conclusions</p> <p>It suggests that administration of essential oil of <it>P. graveolens</it> may be helpful in the prevention of diabetic complications associated with oxidative stress. Our results, therefore, suggest that the rose-scented geranium could be used as a safe alternative antihyperglycemic drug for diabetic patients.</p> http://www.lipidworld.com/content/11/1/81<it>P. graveolens</it>DiabetesGlibenclamideAlloxanRatsAntioxidant activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Boukhris Maher Bouaziz Mohamed Feki Ines Jemai Hedya El Feki Abdelfattah Sayadi Sami |
spellingShingle |
Boukhris Maher Bouaziz Mohamed Feki Ines Jemai Hedya El Feki Abdelfattah Sayadi Sami Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic rats Lipids in Health and Disease <it>P. graveolens</it> Diabetes Glibenclamide Alloxan Rats Antioxidant activity |
author_facet |
Boukhris Maher Bouaziz Mohamed Feki Ines Jemai Hedya El Feki Abdelfattah Sayadi Sami |
author_sort |
Boukhris Maher |
title |
Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic rats |
title_short |
Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic rats |
title_full |
Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic rats |
title_fullStr |
Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic rats |
title_full_unstemmed |
Hypoglycemic and antioxidant effects of leaf essential oil of <it>Pelargonium graveolens</it> L’Hér. in alloxan induced diabetic rats |
title_sort |
hypoglycemic and antioxidant effects of leaf essential oil of <it>pelargonium graveolens</it> l’hér. in alloxan induced diabetic rats |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2012-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Rose-scented geranium (<it>Pelargonium graveolens</it> L’Hér.), which is used in traditional Tunisian folk medicine for the treatment of hyperglycaemia, is widely known as one of the medicinal herbs with the highest antioxidant activity. The present paper is conducted to test the hypoglycemic and antioxidative activities of the leaf essential oil of <it>P. graveolens</it>.</p> <p>Methods</p> <p>The essential oil <it>P. graveolens</it> was administered daily and orally to the rats at two doses of 75 mg/kg and 150 mg/kg body weight (b.w.) for 30 days. The chemical composition of <it>P. graveolens</it> essential oil, body weight, serum glucose, hepatic glycogen, thiobarbituric acid-reactive substances (TBARS), the components of hepatic, and renal and serum antioxidant systems were evaluated. The hypoglycemic effect of rose-scented geranium was compared to that of the known anti-diabetic drug glibenclamide (600 μg/kg b.w.).</p> <p>Results</p> <p>After the administration of two doses of essential oil of <it>Pelargonium graveolens</it> L’Hér. together with glibenclamide which is known by its antidiabetic activities and used as reference (600 μg/kg b.w.), for four weeks, the serum glucose significantly decreased and antioxidant perturbations were restored. The hypoglycemic effect of <it>P. graveolens</it> at the dose of 150 mg/kg b.w. was significantly (<it>p</it>< 0.05) more effective than that of glibenclamide. It is through the histological findings in hepatic and renal tissues of diabetic rats that these beneficial effects of geranium oils were confirmed.</p> <p>Conclusions</p> <p>It suggests that administration of essential oil of <it>P. graveolens</it> may be helpful in the prevention of diabetic complications associated with oxidative stress. Our results, therefore, suggest that the rose-scented geranium could be used as a safe alternative antihyperglycemic drug for diabetic patients.</p> |
topic |
<it>P. graveolens</it> Diabetes Glibenclamide Alloxan Rats Antioxidant activity |
url |
http://www.lipidworld.com/content/11/1/81 |
work_keys_str_mv |
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