The Fascinating Effects of Baicalein on Cancer: A Review
Cancer is one of the leading causes of death worldwide and a major global health problem. In recent decades, the rates of both mortality and morbidity of cancer have rapidly increased for a variety of reasons. Despite treatment options, there are serious side effects associated with chemotherapy dru...
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doaj-2f0c3bb95dc845f48559e1385989d8aa2020-11-25T00:49:15ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-10-011710168110.3390/ijms17101681ijms17101681The Fascinating Effects of Baicalein on Cancer: A ReviewHui Liu0Yonghui Dong1Yutong Gao2Zhipeng Du3Yuting Wang4Peng Cheng5Anmin Chen6Hui Huang7Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaCancer is one of the leading causes of death worldwide and a major global health problem. In recent decades, the rates of both mortality and morbidity of cancer have rapidly increased for a variety of reasons. Despite treatment options, there are serious side effects associated with chemotherapy drugs and multiple forms of drug resistance that significantly reduce their effects. There is an accumulating amount of evidence on the pharmacological activities of baicalein (e.g., anti-inflammatory, antioxidant, antiviral, and antitumor effects). Furthermore, there has been great progress in elucidating the target mechanisms and signaling pathways of baicalein’s anti-cancer potential. The anti-tumor functions of baicalein are mainly due to its capacities to inhibit complexes of cyclins to regulate the cell cycle, to scavenge oxidative radicals, to attenuate mitogen activated protein kinase (MAPK), protein kinase B (Akt) or mammalian target of rapamycin (mTOR) activities, to induce apoptosis by activating caspase-9/-3 and to inhibit tumorinvasion and metastasis by reducing the expression of matrix metalloproteinase-2/-9 (MMP-2/-9). In this review, we focused on the relevant biological mechanisms of baicalein involved in inhibiting various cancers, such as bladder cancer, breast cancer, and ovarian cancer. Moreover, we also summarized the specific mechanisms by which baicalein inhibited the growth of various tumors in vivo. Taken together, baicalein may be developed as a potential, novel anticancer drug to treat tumors.http://www.mdpi.com/1422-0067/17/10/1681baicaleinflavonoidsMAPKAktreactive oxygen species (ROS)cancertherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui Liu Yonghui Dong Yutong Gao Zhipeng Du Yuting Wang Peng Cheng Anmin Chen Hui Huang |
spellingShingle |
Hui Liu Yonghui Dong Yutong Gao Zhipeng Du Yuting Wang Peng Cheng Anmin Chen Hui Huang The Fascinating Effects of Baicalein on Cancer: A Review International Journal of Molecular Sciences baicalein flavonoids MAPK Akt reactive oxygen species (ROS) cancer therapy |
author_facet |
Hui Liu Yonghui Dong Yutong Gao Zhipeng Du Yuting Wang Peng Cheng Anmin Chen Hui Huang |
author_sort |
Hui Liu |
title |
The Fascinating Effects of Baicalein on Cancer: A Review |
title_short |
The Fascinating Effects of Baicalein on Cancer: A Review |
title_full |
The Fascinating Effects of Baicalein on Cancer: A Review |
title_fullStr |
The Fascinating Effects of Baicalein on Cancer: A Review |
title_full_unstemmed |
The Fascinating Effects of Baicalein on Cancer: A Review |
title_sort |
fascinating effects of baicalein on cancer: a review |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2016-10-01 |
description |
Cancer is one of the leading causes of death worldwide and a major global health problem. In recent decades, the rates of both mortality and morbidity of cancer have rapidly increased for a variety of reasons. Despite treatment options, there are serious side effects associated with chemotherapy drugs and multiple forms of drug resistance that significantly reduce their effects. There is an accumulating amount of evidence on the pharmacological activities of baicalein (e.g., anti-inflammatory, antioxidant, antiviral, and antitumor effects). Furthermore, there has been great progress in elucidating the target mechanisms and signaling pathways of baicalein’s anti-cancer potential. The anti-tumor functions of baicalein are mainly due to its capacities to inhibit complexes of cyclins to regulate the cell cycle, to scavenge oxidative radicals, to attenuate mitogen activated protein kinase (MAPK), protein kinase B (Akt) or mammalian target of rapamycin (mTOR) activities, to induce apoptosis by activating caspase-9/-3 and to inhibit tumorinvasion and metastasis by reducing the expression of matrix metalloproteinase-2/-9 (MMP-2/-9). In this review, we focused on the relevant biological mechanisms of baicalein involved in inhibiting various cancers, such as bladder cancer, breast cancer, and ovarian cancer. Moreover, we also summarized the specific mechanisms by which baicalein inhibited the growth of various tumors in vivo. Taken together, baicalein may be developed as a potential, novel anticancer drug to treat tumors. |
topic |
baicalein flavonoids MAPK Akt reactive oxygen species (ROS) cancer therapy |
url |
http://www.mdpi.com/1422-0067/17/10/1681 |
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