Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis
Tuberous sclerosis complex (TSC) is a rare autosomal dominant neurocutaneous syndrome. The phenotype is highly variable and may affect several organ systems, the hallmark of the disease being widespread hamartomas or abnormal growth of normal tissues. Although cardiac rhabdomyomas are the most commo...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-12-01
|
Series: | Diagnostics |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4418/10/12/1031 |
id |
doaj-2f1a435363664d428afcaee5db8e145c |
---|---|
record_format |
Article |
spelling |
doaj-2f1a435363664d428afcaee5db8e145c2020-12-02T00:03:07ZengMDPI AGDiagnostics2075-44182020-12-01101031103110.3390/diagnostics10121031Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous SclerosisZoi Tsoumani0Melanie Greaves1Matthias Schmitt2Gaetano Nucifora3Cardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKCardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKCardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKCardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKTuberous sclerosis complex (TSC) is a rare autosomal dominant neurocutaneous syndrome. The phenotype is highly variable and may affect several organ systems, the hallmark of the disease being widespread hamartomas or abnormal growth of normal tissues. Although cardiac rhabdomyomas are the most common cardiac manifestation of TSC, being developed quite early, even during the second semester of the gestation, they tend to regress spontaneously over a period of months or years. On the other hand, the presence of intramyocardial fat deposition has been significantly associated with brain involvement and other extracardiac manifestations. We report the case of a 37-year-old man with TSC who presented to hospital with loss of consciousness, head injury and amnesia and in whom cardiac magnetic resonance imaging revealed the presence of multiple areas intramyocardial fat deposition.https://www.mdpi.com/2075-4418/10/12/1031cardiac magnetic resonanceintramyocardial fattuberous sclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zoi Tsoumani Melanie Greaves Matthias Schmitt Gaetano Nucifora |
spellingShingle |
Zoi Tsoumani Melanie Greaves Matthias Schmitt Gaetano Nucifora Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis Diagnostics cardiac magnetic resonance intramyocardial fat tuberous sclerosis |
author_facet |
Zoi Tsoumani Melanie Greaves Matthias Schmitt Gaetano Nucifora |
author_sort |
Zoi Tsoumani |
title |
Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis |
title_short |
Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis |
title_full |
Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis |
title_fullStr |
Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis |
title_full_unstemmed |
Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis |
title_sort |
magnetic resonance imaging of intramyocardial fat deposition in tuberous sclerosis |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-12-01 |
description |
Tuberous sclerosis complex (TSC) is a rare autosomal dominant neurocutaneous syndrome. The phenotype is highly variable and may affect several organ systems, the hallmark of the disease being widespread hamartomas or abnormal growth of normal tissues. Although cardiac rhabdomyomas are the most common cardiac manifestation of TSC, being developed quite early, even during the second semester of the gestation, they tend to regress spontaneously over a period of months or years. On the other hand, the presence of intramyocardial fat deposition has been significantly associated with brain involvement and other extracardiac manifestations. We report the case of a 37-year-old man with TSC who presented to hospital with loss of consciousness, head injury and amnesia and in whom cardiac magnetic resonance imaging revealed the presence of multiple areas intramyocardial fat deposition. |
topic |
cardiac magnetic resonance intramyocardial fat tuberous sclerosis |
url |
https://www.mdpi.com/2075-4418/10/12/1031 |
work_keys_str_mv |
AT zoitsoumani magneticresonanceimagingofintramyocardialfatdepositionintuberoussclerosis AT melaniegreaves magneticresonanceimagingofintramyocardialfatdepositionintuberoussclerosis AT matthiasschmitt magneticresonanceimagingofintramyocardialfatdepositionintuberoussclerosis AT gaetanonucifora magneticresonanceimagingofintramyocardialfatdepositionintuberoussclerosis |
_version_ |
1724410506268114944 |