Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum

Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum

The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], and regulates calcium and bone metabolism. Lithocholic acid (LCA), which is a secondary bile acid produced by intestinal bacteria...

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Bibliographic Details
Main Authors:	Michiyasu Ishizawa, Daisuke Akagi, Makoto Makishima
Format:	Article
Language:	English
Published:	MDPI AG 2018-07-01
Series:	International Journal of Molecular Sciences
Subjects:	vitamin D receptor vitamin D lithocholic acid bile acid CYP24A1 TRPV6 calcium metabolism ileum
Online Access:	http://www.mdpi.com/1422-0067/19/7/1975

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