The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model
Schizophrenia is a serious psychiatric illness with an unclear cause. One theory is that demyelination of white matter is one of the main pathological factors involved in the development of schizophrenia. The current study evaluated the protective effects of Areca catechu nut extract (ANE) on a cu...
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doaj-2f3150f0756240f890ebfca9eaac635e2020-11-24T22:48:54ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/426092426092The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination ModelAbulimiti Adilijiang0Teng Guan1Jue He2Kelly Hartle3Wenqiang Wang4XinMin Li5Xia Men Xian Yue Hospital, Xian Yue Road 387-399, Xiamen 361012, ChinaDepartment of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9, CanadaDepartment of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, T6G 2B7, CanadaDepartment of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, T6G 2B7, CanadaXia Men Xian Yue Hospital, Xian Yue Road 387-399, Xiamen 361012, ChinaDepartment of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, T6G 2B7, CanadaSchizophrenia is a serious psychiatric illness with an unclear cause. One theory is that demyelination of white matter is one of the main pathological factors involved in the development of schizophrenia. The current study evaluated the protective effects of Areca catechu nut extract (ANE) on a cuprizone-induced demyelination mouse model. Two doses of ANE (1% and 2%) were administered orally in the diet for 8 weeks. Animals subjected to demyelination showed impaired spatial memory and less social activity. In addition, mice subjected to demyelination displayed significant myelin damage in cortex and demonstrated a higher expression of NG2 and PDGFRα and AMPK activation. ANE treatment not only significantly enhanced cognitive ability and social activity, but also protected myelin against cuprizone toxicity by promoting oligodendrocyte precursor cell (OPC) differentiation. In addition, ANE treatment demonstrated significant dephosphorylation of AMPKα, indicating a regulatory role for ANE in schizophrenia. This study showed that ANE treatment may enhance cognitive ability and social activity by facilitating OPC differentiation and protecting against myelin damage in cortex. Results also suggest the AMPK signaling pathway may be involved in this process.http://dx.doi.org/10.1155/2015/426092 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abulimiti Adilijiang Teng Guan Jue He Kelly Hartle Wenqiang Wang XinMin Li |
spellingShingle |
Abulimiti Adilijiang Teng Guan Jue He Kelly Hartle Wenqiang Wang XinMin Li The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model Evidence-Based Complementary and Alternative Medicine |
author_facet |
Abulimiti Adilijiang Teng Guan Jue He Kelly Hartle Wenqiang Wang XinMin Li |
author_sort |
Abulimiti Adilijiang |
title |
The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model |
title_short |
The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model |
title_full |
The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model |
title_fullStr |
The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model |
title_full_unstemmed |
The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model |
title_sort |
protective effects of areca catechu extract on cognition and social interaction deficits in a cuprizone-induced demyelination model |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2015-01-01 |
description |
Schizophrenia is a serious psychiatric illness with an unclear cause. One theory is that demyelination of white matter is one of the main pathological factors involved in the development of schizophrenia. The current study evaluated the protective effects of Areca catechu nut extract (ANE) on a cuprizone-induced demyelination mouse model. Two doses of ANE (1% and 2%) were administered orally in the diet for 8 weeks. Animals subjected to demyelination showed impaired spatial memory and less social activity. In addition, mice subjected to demyelination displayed significant myelin damage in cortex and demonstrated a higher expression of NG2 and PDGFRα and AMPK activation. ANE treatment not only significantly enhanced cognitive ability and social activity, but also protected myelin against cuprizone toxicity by promoting oligodendrocyte precursor cell (OPC) differentiation. In addition, ANE treatment demonstrated significant dephosphorylation of AMPKα, indicating a regulatory role for ANE in schizophrenia. This study showed that ANE treatment may enhance cognitive ability and social activity by facilitating OPC differentiation and protecting against myelin damage in cortex. Results also suggest the AMPK signaling pathway may be involved in this process. |
url |
http://dx.doi.org/10.1155/2015/426092 |
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