Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders

Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders

The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is known about the complementary clinical value of brain structural phenotypes whe...

Full description

Bibliographic Details
Main Authors:	Nhat Trung Doan, Tobias Kaufmann, Francesco Bettella, Kjetil Nordbø Jørgensen, Christine Lycke Brandt, Torgeir Moberget, Dag Alnæs, Gwenaëlle Douaud, Eugene Duff, Srdjan Djurovic, Ingrid Melle, Torill Ueland, Ingrid Agartz, Ole A. Andreassen, Lars T. Westlye
Format:	Article
Language:	English
Published:	Elsevier 2017-01-01
Series:	NeuroImage: Clinical
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213158217301456

Similar Items

Altered Brain Activation during Emotional Face Processing in Relation to Both Diagnosis and Polygenic Risk of Bipolar Disorder.
by: Martin Tesli, et al.
Published: (2015-01-01)

Assessing brain structural associations with working memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis
by: Christine Lycke Brandt, et al.
Published: (2015-01-01)

Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders
by: Beathe Haatveit, et al.
Published: (2016-01-01)

Neurocognitive decrements are present in intellectually superior schizophrenia
by: Anja eVaskinn, et al.
Published: (2014-05-01)

Association between genetic variation in the oxytocin receptor gene and emotional withdrawal, but not between oxytocin pathway genes and diagnosis in psychotic disorders.
by: Marit eHaram, et al.
Published: (2015-01-01)

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder
by: Agartz, I., et al.
Published: (2021)

Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder
by: Monica Aas, et al.
Published: (2020-05-01)

Vitamin D levels, brain volume, and genetic architecture in patients with psychosis.
by: Akiah Ottesen Berg, et al.
Published: (2018-01-01)

Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population.
by: Costin Leu, et al.
Published: (2020-01-01)

Correction: CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls
by: Martin Tesli, et al.
Published: (2013-01-01)

CACNA1C risk variant and amygdala activity in bipolar disorder, schizophrenia and healthy controls.
by: Martin Tesli, et al.
Published: (2013-01-01)

Correction: Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls.
by: Martin Tesli, et al.
Published: (2013-01-01)

Reading emotions from body movement: a generalized impairment in schizophrenia
by: Anja eVaskinn, et al.
Published: (2016-01-01)

Brain connectivity aberrations in anabolic-androgenic steroid users
by: Lars T. Westlye, et al.
Published: (2017-01-01)

Previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia
by: Agartz Ingrid, et al.
Published: (2011-08-01)

Excessive substance use in bipolar disorder is associated with impaired functioning rather than clinical characteristics, a descriptive study
by: Larsson Sara, et al.
Published: (2010-01-01)

Oxytocin pathway gene networks in the human brain
by: Daniel S. Quintana, et al.
Published: (2019-02-01)

Association between a genetic variant in the serotonin transporter gene (<it>SLC6A4</it>) and suicidal behavior in patients with schizophrenia
by: Lindholm Carlström Eva, et al.
Published: (2012-05-01)

Microarray Analysis of Copy Number Variants on the Human Y Chromosome Reveals Novel and Frequent Duplications Overrepresented in Specific Haplogroups.
by: Martin M Johansson, et al.
Published: (2015-01-01)

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
by: Oleksandr Frei, et al.
Published: (2019-06-01)

The factor structure of social cognition in schizophrenia: Weak evidence for separable domains
by: Anja Vaskinn, et al.
Published: (2021-12-01)

The estrogen hypothesis of Schizophrenia implicates glucose metabolism: Association study in three independent samples
by: Timm Sally, et al.
Published: (2008-05-01)

Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia
by: Mona K. Otnæss, et al.
Published: (2009-06-01)

Brain expressed microRNAs implicated in schizophrenia etiology.
by: Thomas Hansen, et al.
Published: (2007-01-01)

Autoantibodies to the N-Methyl-D-Aspartate Receptor in Adolescents With Early Onset Psychosis and Healthy Controls
by: Kristine Engen, et al.
Published: (2020-07-01)

Phenotypically independent profiles relevant to mental health are genetically correlated
by: Daniel Roelfs, et al.
Published: (2021-04-01)

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin
by: Luis G. Leal, et al.
Published: (2020-06-01)

Symptom Profiles in Psychotic Disorder Not Otherwise Specified
by: Line Widing, et al.
Published: (2020-11-01)

Perceived and experienced stigma in first-episode psychosis: A 1-year follow-up study
by: Carmen Simonsen, et al.
Published: (2019-11-01)

Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry
by: Geneviève Richard, et al.
Published: (2018-11-01)

Correction: Connection between Genetic and Clinical Data in Bipolar Disorder
by: Erling Mellerup, et al.
Published: (2013-01-01)

Connection between genetic and clinical data in bipolar disorder.
by: Erling Mellerup, et al.
Published: (2012-01-01)

Correction: Connection between Genetic and Clinical Data in Bipolar Disorder.
by: Erling Mellerup, et al.
Published: (2013-01-01)

Polygenic and miltufactorial disorders
by: Pajović Snežana B.
Published: (2007-01-01)

Apathy is associated with executive functioning in first episode psychosis
by: Agartz Ingrid, et al.
Published: (2009-01-01)

Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder
by: Wenhao Jiang, et al.
Published: (2020-01-01)

Probing the Association between Early Evolutionary Markers and Schizophrenia.
by: Saurabh Srinivasan, et al.
Published: (2017-01-01)

Polygenic Influence on Educational Attainment
by: Benjamin W. Domingue, et al.
Published: (2015-08-01)

Polygenic variation in wild drosophila
by: Walker, S. M.
Published: (1973)

Population-based body–brain mapping links brain morphology with anthropometrics and body composition
by: Tiril P. Gurholt, et al.
Published: (2021-05-01)