Conjugate addition–enantioselective protonation reactions
The addition of nucleophiles to electron-deficient alkenes represents one of the more general and commonly used strategies for the convergent assembly of more complex structures from simple precursors. In this review the addition of diverse protic and organometallic nucleophiles to electron-deficien...
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.12.116 |
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doaj-2f35b0654fe24aa99cf4417dab417e292021-03-02T10:12:22ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972016-06-011211203122810.3762/bjoc.12.1161860-5397-12-116Conjugate addition–enantioselective protonation reactionsJames P. Phelan0Jonathan A. Ellman1Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520, USADepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520, USAThe addition of nucleophiles to electron-deficient alkenes represents one of the more general and commonly used strategies for the convergent assembly of more complex structures from simple precursors. In this review the addition of diverse protic and organometallic nucleophiles to electron-deficient alkenes followed by enantioselective protonation is summarized. Reactions are first categorized by the type of electron-deficient alkene and then are further classified according to whether catalysis is achieved with chiral Lewis acids, organocatalysts, or transition metals.https://doi.org/10.3762/bjoc.12.116asymmetric catalysisconjugate additionenantioselective protonationenolate |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
James P. Phelan Jonathan A. Ellman |
| spellingShingle |
James P. Phelan Jonathan A. Ellman Conjugate addition–enantioselective protonation reactions Beilstein Journal of Organic Chemistry asymmetric catalysis conjugate addition enantioselective protonation enolate |
| author_facet |
James P. Phelan Jonathan A. Ellman |
| author_sort |
James P. Phelan |
| title |
Conjugate addition–enantioselective protonation reactions |
| title_short |
Conjugate addition–enantioselective protonation reactions |
| title_full |
Conjugate addition–enantioselective protonation reactions |
| title_fullStr |
Conjugate addition–enantioselective protonation reactions |
| title_full_unstemmed |
Conjugate addition–enantioselective protonation reactions |
| title_sort |
conjugate addition–enantioselective protonation reactions |
| publisher |
Beilstein-Institut |
| series |
Beilstein Journal of Organic Chemistry |
| issn |
1860-5397 |
| publishDate |
2016-06-01 |
| description |
The addition of nucleophiles to electron-deficient alkenes represents one of the more general and commonly used strategies for the convergent assembly of more complex structures from simple precursors. In this review the addition of diverse protic and organometallic nucleophiles to electron-deficient alkenes followed by enantioselective protonation is summarized. Reactions are first categorized by the type of electron-deficient alkene and then are further classified according to whether catalysis is achieved with chiral Lewis acids, organocatalysts, or transition metals. |
| topic |
asymmetric catalysis conjugate addition enantioselective protonation enolate |
| url |
https://doi.org/10.3762/bjoc.12.116 |
| work_keys_str_mv |
AT jamespphelan conjugateadditionenantioselectiveprotonationreactions AT jonathanaellman conjugateadditionenantioselectiveprotonationreactions |
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