Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapy
Subacute Sclerosing Panencephalitis (SSPE) in HIV-infected children is a scarcely reported entity with previous reports describing fulminant course. The impact of highly active antiretroviral therapy (HAART) in altering its course remains unknown. We describe a child with HIV infection, who develope...
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Wolters Kluwer Medknow Publications
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doaj-2f3f23f92aa9417bad6c146b9e81dce52020-11-24T23:10:16ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492015-01-01181969810.4103/0972-2327.144299Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapyKarthik MuthusamySangeetha YoganathanMaya Mary ThomasMathew AlexanderValsan Philip VergheseSubacute Sclerosing Panencephalitis (SSPE) in HIV-infected children is a scarcely reported entity with previous reports describing fulminant course. The impact of highly active antiretroviral therapy (HAART) in altering its course remains unknown. We describe a child with HIV infection, who developed measles at 5 months of age and later developed SSPE at 14 years of age, remaining stable at 7 month follow-up, while on HAART for WHO (World Health Organisation) stage IV disease. The dynamics of HIV-related immunosuppression has an impact on the clinical course of SSPE. Contrary to reported cases of fulminant progression, a classic presentation with slow progression can be expected in children on HAART. We reemphasize the recommendation of “early measles vaccination” to prevent measles infection and subsequent SSPE in these children with an increasingly good life expectancy in the era of HAART.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=1;spage=96;epage=98;aulast=MuthusamyEarly measles vaccination in HIV infected childrenHAARTSSPE in HIV infected children |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karthik Muthusamy Sangeetha Yoganathan Maya Mary Thomas Mathew Alexander Valsan Philip Verghese |
spellingShingle |
Karthik Muthusamy Sangeetha Yoganathan Maya Mary Thomas Mathew Alexander Valsan Philip Verghese Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapy Annals of Indian Academy of Neurology Early measles vaccination in HIV infected children HAART SSPE in HIV infected children |
author_facet |
Karthik Muthusamy Sangeetha Yoganathan Maya Mary Thomas Mathew Alexander Valsan Philip Verghese |
author_sort |
Karthik Muthusamy |
title |
Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapy |
title_short |
Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapy |
title_full |
Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapy |
title_fullStr |
Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapy |
title_full_unstemmed |
Subacute sclerosing panencephalitis in a child with human immunodeficiency virus (HIV) infection on antiretroviral therapy |
title_sort |
subacute sclerosing panencephalitis in a child with human immunodeficiency virus (hiv) infection on antiretroviral therapy |
publisher |
Wolters Kluwer Medknow Publications |
series |
Annals of Indian Academy of Neurology |
issn |
0972-2327 1998-3549 |
publishDate |
2015-01-01 |
description |
Subacute Sclerosing Panencephalitis (SSPE) in HIV-infected children is a scarcely reported entity with previous reports describing fulminant course. The impact of highly active antiretroviral therapy (HAART) in altering its course remains unknown. We describe a child with HIV infection, who developed measles at 5 months of age and later developed SSPE at 14 years of age, remaining stable at 7 month follow-up, while on HAART for WHO (World Health Organisation) stage IV disease. The dynamics of HIV-related immunosuppression has an impact on the clinical course of SSPE. Contrary to reported cases of fulminant progression, a classic presentation with slow progression can be expected in children on HAART. We reemphasize the recommendation of “early measles vaccination” to prevent measles infection and subsequent SSPE in these children with an increasingly good life expectancy in the era of HAART. |
topic |
Early measles vaccination in HIV infected children HAART SSPE in HIV infected children |
url |
http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=1;spage=96;epage=98;aulast=Muthusamy |
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