Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence
Neighborhood disadvantage has consistently been linked to alterations in brain structure; however, positive environmental (e.g., positive parenting) and psychological factors (e.g., temperament) may buffer these effects. We aimed to investigate associations between neighborhood disadvantage and devi...
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doaj-2f50b03ea32d4195a57fd931b214d67c2021-08-18T04:21:43ZengElsevierDevelopmental Cognitive Neuroscience1878-92932021-10-0151101002Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescenceDivyangana Rakesh0Vanessa Cropley1Andrew Zalesky2Nandita Vijayakumar3Nicholas B. Allen4Sarah Whittle5Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia; Corresponding authors at: Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Alan Gilbert Building (level 3), 161 Barry Street, 3053 VIC, Melbourne, Australia.Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, AustraliaMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia; Melbourne School of Engineering, University of Melbourne, Melbourne, AustraliaSchool of Psychology, Deakin University, Melbourne, AustraliaDepartment of Psychology, University of Oregon, Eugene, USAMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia; Corresponding authors at: Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Alan Gilbert Building (level 3), 161 Barry Street, 3053 VIC, Melbourne, Australia.Neighborhood disadvantage has consistently been linked to alterations in brain structure; however, positive environmental (e.g., positive parenting) and psychological factors (e.g., temperament) may buffer these effects. We aimed to investigate associations between neighborhood disadvantage and deviations from typical neurodevelopmental trajectories during adolescence, and examine the moderating role of positive parenting and temperamental effortful control (EC). Using a large dataset (n = 1313), a normative model of brain morphology was established, which was then used to predict the age of youth from a longitudinal dataset (n = 166, three time-points at age 12, 16, and 19). Using linear mixed models, we investigated whether trajectories of the difference between brain-predicted-age and chronological age (brainAGE) were associated with neighborhood disadvantage, and whether positive parenting (positive behavior during a problem-solving task) and EC moderated these associations. We found that neighborhood disadvantage was associated with positive brainAGE during early adolescence and a deceleration (decreasing brainAGE) thereafter. EC moderated this association such that in disadvantaged adolescents, low EC was associated with delayed development (negative brainAGE) during late adolescence. Findings provide evidence for complex associations between environmental and psychological factors, and brain maturation. They suggest that neighborhood disadvantage may have long-term effects on neurodevelopment during adolescence, but high EC could buffer these effects.http://www.sciencedirect.com/science/article/pii/S187892932100092Xadolescencesocioeconomic statustemperamental effortful controlparentinglongitudinalMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Divyangana Rakesh Vanessa Cropley Andrew Zalesky Nandita Vijayakumar Nicholas B. Allen Sarah Whittle |
spellingShingle |
Divyangana Rakesh Vanessa Cropley Andrew Zalesky Nandita Vijayakumar Nicholas B. Allen Sarah Whittle Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence Developmental Cognitive Neuroscience adolescence socioeconomic status temperamental effortful control parenting longitudinal MRI |
author_facet |
Divyangana Rakesh Vanessa Cropley Andrew Zalesky Nandita Vijayakumar Nicholas B. Allen Sarah Whittle |
author_sort |
Divyangana Rakesh |
title |
Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence |
title_short |
Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence |
title_full |
Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence |
title_fullStr |
Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence |
title_full_unstemmed |
Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence |
title_sort |
neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence |
publisher |
Elsevier |
series |
Developmental Cognitive Neuroscience |
issn |
1878-9293 |
publishDate |
2021-10-01 |
description |
Neighborhood disadvantage has consistently been linked to alterations in brain structure; however, positive environmental (e.g., positive parenting) and psychological factors (e.g., temperament) may buffer these effects. We aimed to investigate associations between neighborhood disadvantage and deviations from typical neurodevelopmental trajectories during adolescence, and examine the moderating role of positive parenting and temperamental effortful control (EC). Using a large dataset (n = 1313), a normative model of brain morphology was established, which was then used to predict the age of youth from a longitudinal dataset (n = 166, three time-points at age 12, 16, and 19). Using linear mixed models, we investigated whether trajectories of the difference between brain-predicted-age and chronological age (brainAGE) were associated with neighborhood disadvantage, and whether positive parenting (positive behavior during a problem-solving task) and EC moderated these associations. We found that neighborhood disadvantage was associated with positive brainAGE during early adolescence and a deceleration (decreasing brainAGE) thereafter. EC moderated this association such that in disadvantaged adolescents, low EC was associated with delayed development (negative brainAGE) during late adolescence. Findings provide evidence for complex associations between environmental and psychological factors, and brain maturation. They suggest that neighborhood disadvantage may have long-term effects on neurodevelopment during adolescence, but high EC could buffer these effects. |
topic |
adolescence socioeconomic status temperamental effortful control parenting longitudinal MRI |
url |
http://www.sciencedirect.com/science/article/pii/S187892932100092X |
work_keys_str_mv |
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