Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy
<b>: </b>Phytochemicals and their metabolites are not considered essential nutrients in humans, although an increasing number of well-conducted studies are linking their higher intake with a lower incidence of non-communicable diseases, including cancer. This review summarizes the curren...
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doaj-2f6739fe02834e2dad48fc39227de3922020-11-25T03:31:01ZengMDPI AGMolecules1420-30492020-08-01253531353110.3390/molecules25153531Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and TherapyDanielly C. Ferraz da Costa0Luciana Pereira Rangel1Julia Quarti2Ronimara A. Santos3Jerson L. Silva4Eliane Fialho5Departamento de Nutrição Básica e Experimental, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-013, BrazilFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilDepartamento de Nutrição Básica e Experimental, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilDepartamento de Nutrição Básica e Experimental, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-013, BrazilPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilDepartamento de Nutrição Básica e Experimental, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil<b>: </b>Phytochemicals and their metabolites are not considered essential nutrients in humans, although an increasing number of well-conducted studies are linking their higher intake with a lower incidence of non-communicable diseases, including cancer. This review summarizes the current findings concerning the molecular mechanisms of bioactive compounds from grapes and red wine and their metabolites on breast cancer—the most commonly occurring cancer in women—chemoprevention and treatment. Flavonoid compounds like flavonols, monomeric catechins, proanthocyanidins, anthocyanins, anthocyanidins and non-flavonoid phenolic compounds, such as resveratrol, as well as their metabolites, are discussed with respect to structure and metabolism/bioavailability. In addition, a broad discussion regarding in vitro, in vivo and clinical trials about the chemoprevention and therapy using these molecules is presented.https://www.mdpi.com/1420-3049/25/15/3531bioactive compoundsmetaboliteswinegrapesbreast cancerchemoprevention |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Danielly C. Ferraz da Costa Luciana Pereira Rangel Julia Quarti Ronimara A. Santos Jerson L. Silva Eliane Fialho |
spellingShingle |
Danielly C. Ferraz da Costa Luciana Pereira Rangel Julia Quarti Ronimara A. Santos Jerson L. Silva Eliane Fialho Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy Molecules bioactive compounds metabolites wine grapes breast cancer chemoprevention |
author_facet |
Danielly C. Ferraz da Costa Luciana Pereira Rangel Julia Quarti Ronimara A. Santos Jerson L. Silva Eliane Fialho |
author_sort |
Danielly C. Ferraz da Costa |
title |
Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy |
title_short |
Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy |
title_full |
Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy |
title_fullStr |
Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy |
title_full_unstemmed |
Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy |
title_sort |
bioactive compounds and metabolites from grapes and red wine in breast cancer chemoprevention and therapy |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-08-01 |
description |
<b>: </b>Phytochemicals and their metabolites are not considered essential nutrients in humans, although an increasing number of well-conducted studies are linking their higher intake with a lower incidence of non-communicable diseases, including cancer. This review summarizes the current findings concerning the molecular mechanisms of bioactive compounds from grapes and red wine and their metabolites on breast cancer—the most commonly occurring cancer in women—chemoprevention and treatment. Flavonoid compounds like flavonols, monomeric catechins, proanthocyanidins, anthocyanins, anthocyanidins and non-flavonoid phenolic compounds, such as resveratrol, as well as their metabolites, are discussed with respect to structure and metabolism/bioavailability. In addition, a broad discussion regarding in vitro, in vivo and clinical trials about the chemoprevention and therapy using these molecules is presented. |
topic |
bioactive compounds metabolites wine grapes breast cancer chemoprevention |
url |
https://www.mdpi.com/1420-3049/25/15/3531 |
work_keys_str_mv |
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