Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)

Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)

Chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is a non-bacterial osteitis of yet unknown origin. Secondary to the absence of both high-titer autoantibodies and autoreactive T lymphocytes, and the association with other autoimmune...

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Main Authors: Sigrun R. Hofmann, Angela Roesen-Wolff, Gabriele Hahn, Christian M. Hedrich
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Rheumatology
Online Access:http://dx.doi.org/10.1155/2012/310206
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spelling doaj-2f68b2aa5a5740e480547b8615e322d52020-11-25T01:12:47ZengHindawi LimitedInternational Journal of Rheumatology1687-92601687-92792012-01-01201210.1155/2012/310206310206Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)Sigrun R. Hofmann0Angela Roesen-Wolff1Gabriele Hahn2Christian M. Hedrich3Department of Pediatrics, University Hospital Carl Gustav Carus, Fetscherstraβe 74, 01307 Dresden, GermanyDepartment of Pediatrics, University Hospital Carl Gustav Carus, Fetscherstraβe 74, 01307 Dresden, GermanyDepartment of Pediatric Radiology, University Hospital Carl Gustav Carus, 01307 Dresden, GermanyDepartment of Pediatrics, University Hospital Carl Gustav Carus, Fetscherstraβe 74, 01307 Dresden, GermanyChronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is a non-bacterial osteitis of yet unknown origin. Secondary to the absence of both high-titer autoantibodies and autoreactive T lymphocytes, and the association with other autoimmune diseases, it was recently reclassified as an autoinflammatory disorder of the musculoskeletal system. Since its etiology is largely unknown, the diagnosis is based on clinical criteria, and treatment is empiric and not always successful. In this paper, we summarize recent advances in the understanding of possible etiopathogenetic mechanisms in CNO.http://dx.doi.org/10.1155/2012/310206
collection DOAJ
language English
format Article
sources DOAJ
author Sigrun R. Hofmann
Angela Roesen-Wolff
Gabriele Hahn
Christian M. Hedrich
spellingShingle Sigrun R. Hofmann
Angela Roesen-Wolff
Gabriele Hahn
Christian M. Hedrich
Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
International Journal of Rheumatology
author_facet Sigrun R. Hofmann
Angela Roesen-Wolff
Gabriele Hahn
Christian M. Hedrich
author_sort Sigrun R. Hofmann
title Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
title_short Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
title_full Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
title_fullStr Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
title_full_unstemmed Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
title_sort update: cytokine dysregulation in chronic nonbacterial osteomyelitis (cno)
publisher Hindawi Limited
series International Journal of Rheumatology
issn 1687-9260
1687-9279
publishDate 2012-01-01
description Chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is a non-bacterial osteitis of yet unknown origin. Secondary to the absence of both high-titer autoantibodies and autoreactive T lymphocytes, and the association with other autoimmune diseases, it was recently reclassified as an autoinflammatory disorder of the musculoskeletal system. Since its etiology is largely unknown, the diagnosis is based on clinical criteria, and treatment is empiric and not always successful. In this paper, we summarize recent advances in the understanding of possible etiopathogenetic mechanisms in CNO.
url http://dx.doi.org/10.1155/2012/310206
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AT gabrielehahn updatecytokinedysregulationinchronicnonbacterialosteomyelitiscno
AT christianmhedrich updatecytokinedysregulationinchronicnonbacterialosteomyelitiscno
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