Tumor Necrosis Factor α Increases Neuronal Vulnerability to Excitotoxic Necrosis by Inducing Expression of the AMPA–Glutamate Receptor Subunit GluR1 via an Acid Sphingomyelinase- and NF-κB-Dependent Mechanism
Acid sphingomyelinase (ASMase) and NF-κB participate in tumor necrosis factor α (TNFα) signal transduction. Mice in which the genes encoding ASMase or the p50 subunit of NF-κB are disrupted have been reported to be less vulnerable than wild-type mice to focal brain ischemia. We now demonstrate selec...
Main Authors: | ZaiFang Yu, Guanjun Cheng, Xiaoming Wen, Gary D. Wu, Wang-Tso Lee, David Pleasure |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2002-10-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996102905309 |
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