Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease
Introduction Identification of disease-specific diagnostic and prognostic biomarkers which would enable early detection and follow-up of Parkinson’s disease (PD) is a crucial problem. Recently, we confirmed the presence of adaptive immune response against different glial-derived antigens in PD. Obj...
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doaj-2f8c5430298343ae958acf488cde4c182020-11-24T23:47:13ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632016-06-0123239039310.5604/12321966.120399872436Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s diseaseEwa Papuć0Barbara Wilczyńska1Konrad Rejdak2Department of Neurology, Medical University of Lublin, PolandChair and Department of Clinical Immunology, Medical University of Lublin, PolandDepartment of Neurology, Medical University of Lublin, PolandIntroduction Identification of disease-specific diagnostic and prognostic biomarkers which would enable early detection and follow-up of Parkinson’s disease (PD) is a crucial problem. Recently, we confirmed the presence of adaptive immune response against different glial-derived antigens in PD. Objective The aim of the study was to assess humoral response against myelin-associated glycoprotein (MAG) on a larger group of PD patients. IgM autoantibodies against MAG were measured by an ELISA system in 66 PD patients and 66 control subjects. Results The study confirmed a significantly increased production of anti-MAG IgM antibodies in parkinsonian patients (p 0.05). The results provide evidence for activation of humoral response against MAG in PD patients, but argue against the utility of anti-MAG antibodies as biomarkers of disease severity. The results additionally indicate the potential protective role of autoimmunity in maintaining the body’s homeostasis, which may involve the clearance of abnormal proteins. Further studies are necessary to confirm the role of anti-MAG antibodies as biomarkers of PD, especially in relation to other neurodegenerative disorders.http://www.journalssystem.com/aaem/Humoral-response-against-myelin-associated-glycoprotein-reflects-oligodendroglial-degeneration-in-Parkinson-s-disease,72436,0,2.htmlanti-MAG antibodieshumoral responseimmune systemglial cellsParkinson’s disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ewa Papuć Barbara Wilczyńska Konrad Rejdak |
spellingShingle |
Ewa Papuć Barbara Wilczyńska Konrad Rejdak Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease Annals of Agricultural and Environmental Medicine anti-MAG antibodies humoral response immune system glial cells Parkinson’s disease |
author_facet |
Ewa Papuć Barbara Wilczyńska Konrad Rejdak |
author_sort |
Ewa Papuć |
title |
Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease |
title_short |
Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease |
title_full |
Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease |
title_fullStr |
Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease |
title_full_unstemmed |
Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease |
title_sort |
humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in parkinson’s disease |
publisher |
Institute of Rural Health |
series |
Annals of Agricultural and Environmental Medicine |
issn |
1232-1966 1898-2263 |
publishDate |
2016-06-01 |
description |
Introduction
Identification of disease-specific diagnostic and prognostic biomarkers which would enable early detection and follow-up of Parkinson’s disease (PD) is a crucial problem. Recently, we confirmed the presence of adaptive immune response against different glial-derived antigens in PD.
Objective
The aim of the study was to assess humoral response against myelin-associated glycoprotein (MAG) on a larger group of PD patients. IgM autoantibodies against MAG were measured by an ELISA system in 66 PD patients and 66 control subjects.
Results
The study confirmed a significantly increased production of anti-MAG IgM antibodies in parkinsonian patients (p 0.05). The results provide evidence for activation of humoral response against MAG in PD patients, but argue against the utility of anti-MAG antibodies as biomarkers of disease severity. The results additionally indicate the potential protective role of autoimmunity in maintaining the body’s homeostasis, which may involve the clearance of abnormal proteins. Further studies are necessary to confirm the role of anti-MAG antibodies as biomarkers of PD, especially in relation to other neurodegenerative disorders. |
topic |
anti-MAG antibodies humoral response immune system glial cells Parkinson’s disease |
url |
http://www.journalssystem.com/aaem/Humoral-response-against-myelin-associated-glycoprotein-reflects-oligodendroglial-degeneration-in-Parkinson-s-disease,72436,0,2.html |
work_keys_str_mv |
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1725490971951497216 |