Memory maintenance in synapses with calcium-based plasticity in the presence of background activity.

Most models of learning and memory assume that memories are maintained in neuronal circuits by persistent synaptic modifications induced by specific patterns of pre- and postsynaptic activity. For this scenario to be viable, synaptic modifications must survive the ubiquitous ongoing activity present...

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Bibliographic Details
Main Authors: David Higgins, Michael Graupner, Nicolas Brunel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4183374?pdf=render