Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats
Abstract Protaetia brevitarsis seulensis is an animal‐based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2021-10-01
|
Series: | Food Science & Nutrition |
Subjects: | |
Online Access: | https://doi.org/10.1002/fsn3.2460 |
id |
doaj-2f94f966a27a40108bbe8257ce391670 |
---|---|
record_format |
Article |
spelling |
doaj-2f94f966a27a40108bbe8257ce3916702021-10-08T05:24:45ZengWileyFood Science & Nutrition2048-71772021-10-019105361536910.1002/fsn3.2460Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in ratsYun‐Soo Seo0Na‐Rea Shin1Hyeon Hwa Nam2Jun‐Ho Song3Byeong Cheol Moon4Goya Choi5In‐Sik Shin6Joong‐Sun Kim7Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju‐si KoreaCollege of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju KoreaHerbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju‐si KoreaHerbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju‐si KoreaHerbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju‐si KoreaHerbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju‐si KoreaCollege of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju KoreaHerbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju‐si KoreaAbstract Protaetia brevitarsis seulensis is an animal‐based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of P. brevitarsis on a testosterone‐induced benign prostatic hyperplasia (BPH) rat model. To establish the BPH model, the animals were administered a subcutaneous injection of testosterone daily for 28 days. P. brevitarsis was administered by oral gavage at doses of 12.5, 25, and 50 mg/kg for 28 days, along with testosterone injection. P. brevitarsis treatment markedly decreased the absolute and relative prostate weight of BPH animals. The levels of dihydrotestosterone was reduced in P. brevitarsis‐treated animals compared to those in the BPH animals. Histological analysis of the prostate showed that P. brevitarsis treatment effectively suppressed the testosterone‐induced hyperplasia of prostatic epithelial cells, which was accompanied by reductions in the PCNA and Ki‐67 expressions in prostatic tissues. These results indicate that P. brevitarsis effectively suppresses testosterone‐induced development of BPH, and thus, is a potential therapeutic agent for BPH.https://doi.org/10.1002/fsn3.2460benign prostatic hyperplasiadihydrotestosteroneProtaetia brevitarsis seulensisontestosterone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yun‐Soo Seo Na‐Rea Shin Hyeon Hwa Nam Jun‐Ho Song Byeong Cheol Moon Goya Choi In‐Sik Shin Joong‐Sun Kim |
spellingShingle |
Yun‐Soo Seo Na‐Rea Shin Hyeon Hwa Nam Jun‐Ho Song Byeong Cheol Moon Goya Choi In‐Sik Shin Joong‐Sun Kim Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats Food Science & Nutrition benign prostatic hyperplasia dihydrotestosterone Protaetia brevitarsis seulensison testosterone |
author_facet |
Yun‐Soo Seo Na‐Rea Shin Hyeon Hwa Nam Jun‐Ho Song Byeong Cheol Moon Goya Choi In‐Sik Shin Joong‐Sun Kim |
author_sort |
Yun‐Soo Seo |
title |
Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats |
title_short |
Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats |
title_full |
Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats |
title_fullStr |
Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats |
title_full_unstemmed |
Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats |
title_sort |
effects of larval extracts from identified protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats |
publisher |
Wiley |
series |
Food Science & Nutrition |
issn |
2048-7177 |
publishDate |
2021-10-01 |
description |
Abstract Protaetia brevitarsis seulensis is an animal‐based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of P. brevitarsis on a testosterone‐induced benign prostatic hyperplasia (BPH) rat model. To establish the BPH model, the animals were administered a subcutaneous injection of testosterone daily for 28 days. P. brevitarsis was administered by oral gavage at doses of 12.5, 25, and 50 mg/kg for 28 days, along with testosterone injection. P. brevitarsis treatment markedly decreased the absolute and relative prostate weight of BPH animals. The levels of dihydrotestosterone was reduced in P. brevitarsis‐treated animals compared to those in the BPH animals. Histological analysis of the prostate showed that P. brevitarsis treatment effectively suppressed the testosterone‐induced hyperplasia of prostatic epithelial cells, which was accompanied by reductions in the PCNA and Ki‐67 expressions in prostatic tissues. These results indicate that P. brevitarsis effectively suppresses testosterone‐induced development of BPH, and thus, is a potential therapeutic agent for BPH. |
topic |
benign prostatic hyperplasia dihydrotestosterone Protaetia brevitarsis seulensison testosterone |
url |
https://doi.org/10.1002/fsn3.2460 |
work_keys_str_mv |
AT yunsooseo effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats AT nareashin effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats AT hyeonhwanam effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats AT junhosong effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats AT byeongcheolmoon effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats AT goyachoi effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats AT insikshin effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats AT joongsunkim effectsoflarvalextractsfromidentifiedprotaetiabrevitarsisseulensisagainstbenignprostatichyperplasiainducedbytestosteroneinrats |
_version_ |
1716838718116986880 |