Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility
Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published res...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | Gastroenterology Research and Practice |
Online Access: | http://dx.doi.org/10.1155/2015/764163 |
id |
doaj-2f97be7b270d409b92b41d8b100dc64a |
---|---|
record_format |
Article |
spelling |
doaj-2f97be7b270d409b92b41d8b100dc64a2020-11-24T21:33:19ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/764163764163Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer SusceptibilityQing Ni0Anlai Ji1Junfeng Yin2Xiangjun Wang3Xinnong Liu4Department of General Surgery, First People’s Hospital of Yangzhou, Yangzhou, Jiangsu 225001, ChinaDepartment of General Surgery, First People’s Hospital of Yangzhou, Yangzhou, Jiangsu 225001, ChinaDepartment of General Surgery, First People’s Hospital of Yangzhou, Yangzhou, Jiangsu 225001, ChinaDepartment of General Surgery, First People’s Hospital of Yangzhou, Yangzhou, Jiangsu 225001, ChinaDepartment of General Surgery, First People’s Hospital of Yangzhou, Yangzhou, Jiangsu 225001, ChinaBackground. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI). Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model. Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect.http://dx.doi.org/10.1155/2015/764163 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qing Ni Anlai Ji Junfeng Yin Xiangjun Wang Xinnong Liu |
spellingShingle |
Qing Ni Anlai Ji Junfeng Yin Xiangjun Wang Xinnong Liu Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility Gastroenterology Research and Practice |
author_facet |
Qing Ni Anlai Ji Junfeng Yin Xiangjun Wang Xinnong Liu |
author_sort |
Qing Ni |
title |
Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility |
title_short |
Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility |
title_full |
Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility |
title_fullStr |
Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility |
title_full_unstemmed |
Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility |
title_sort |
effects of two common polymorphisms rs2910164 in mir-146a and rs11614913 in mir-196a2 on gastric cancer susceptibility |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2015-01-01 |
description |
Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI). Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model. Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect. |
url |
http://dx.doi.org/10.1155/2015/764163 |
work_keys_str_mv |
AT qingni effectsoftwocommonpolymorphismsrs2910164inmir146aandrs11614913inmir196a2ongastriccancersusceptibility AT anlaiji effectsoftwocommonpolymorphismsrs2910164inmir146aandrs11614913inmir196a2ongastriccancersusceptibility AT junfengyin effectsoftwocommonpolymorphismsrs2910164inmir146aandrs11614913inmir196a2ongastriccancersusceptibility AT xiangjunwang effectsoftwocommonpolymorphismsrs2910164inmir146aandrs11614913inmir196a2ongastriccancersusceptibility AT xinnongliu effectsoftwocommonpolymorphismsrs2910164inmir146aandrs11614913inmir196a2ongastriccancersusceptibility |
_version_ |
1725953707428806656 |