A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
VPS15 is known as a VPS34-associated protein that functions in intracellular trafficking and autophagy. Here the authors identify a role for VPS15 in ciliopathy and ciliary phenotypes, and show that it interacts with GM130 and functions in IFT20-dependent cis-Golgi to cilium trafficking.
Bibliographic Details
| Main Authors: |
Corinne Stoetzel,
Séverine Bär,
Johan-Owen De Craene,
Sophie Scheidecker,
Christelle Etard,
Johana Chicher,
Jennifer R. Reck,
Isabelle Perrault,
Véronique Geoffroy,
Kirsley Chennen,
Uwe Strähle,
Philippe Hammann,
Sylvie Friant,
Hélène Dollfus |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2016-11-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/ncomms13586
|
|---|
