Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT
It has been shown that patients with heart failure have high levels of brain or type B natriuretic peptide (BNP), and that there is a correlation between these and the severity of their condition. Many studies report that monitoring BNP levels could be a sensitive method for diagnosing heart failure...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer
2016-08-01
|
Series: | Egyptian Journal of Critical Care Medicine |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2090730316300251 |
id |
doaj-2fad050630ae41a596092d6fc8f085ad |
---|---|
record_format |
Article |
spelling |
doaj-2fad050630ae41a596092d6fc8f085ad2020-11-25T02:21:13ZengWolters KluwerEgyptian Journal of Critical Care Medicine2090-73032016-08-01429710310.1016/j.ejccm.2016.05.003Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRTAmr NawarWael SamyHisham ElaasarAmal RizkSherif MokhtarIt has been shown that patients with heart failure have high levels of brain or type B natriuretic peptide (BNP), and that there is a correlation between these and the severity of their condition. Many studies report that monitoring BNP levels could be a sensitive method for diagnosing heart failure and performing risk stratification, and that they could act as an independent predictor of adverse events helping clinicians arrive at a prognosis. To achieve this purpose we studied 30 patients with CHF (27 males, mean age 57 years) undergoing CRT implantation. The main finding of our study was that CRT exerted a substantial reduction in plasma BNP levels among responders, but no significant change in nonresponders after 3 months follow-up, only responders showed a significant decrease in plasma BNP levels (229.64 pg/ml ± 111) as compared to non-responders (468 pg/ml ± 96) P value <0.01. Response could be predicted with a cut-off value of 360 pg/ml, with a sensitivity and specificity of 90.9% and 87.5%, respectively. In conclusion, BNP monitoring is potentially a good prognostic indicator of LV functional recovery and reverse remodeling after CRT can accurately identify echocardiographic responders after CRT. Percentage change in plasma BNP levels from baseline to 3 months was the strongest predictor of long-term response to CRT and may have potential to predict outcome.http://www.sciencedirect.com/science/article/pii/S2090730316300251BNPCRTHeart failure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amr Nawar Wael Samy Hisham Elaasar Amal Rizk Sherif Mokhtar |
spellingShingle |
Amr Nawar Wael Samy Hisham Elaasar Amal Rizk Sherif Mokhtar Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT Egyptian Journal of Critical Care Medicine BNP CRT Heart failure |
author_facet |
Amr Nawar Wael Samy Hisham Elaasar Amal Rizk Sherif Mokhtar |
author_sort |
Amr Nawar |
title |
Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
title_short |
Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
title_full |
Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
title_fullStr |
Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
title_full_unstemmed |
Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
title_sort |
usefulness of plasma b type natriuretic peptide as a predictor to identify responders following crt |
publisher |
Wolters Kluwer |
series |
Egyptian Journal of Critical Care Medicine |
issn |
2090-7303 |
publishDate |
2016-08-01 |
description |
It has been shown that patients with heart failure have high levels of brain or type B natriuretic peptide (BNP), and that there is a correlation between these and the severity of their condition. Many studies report that monitoring BNP levels could be a sensitive method for diagnosing heart failure and performing risk stratification, and that they could act as an independent predictor of adverse events helping clinicians arrive at a prognosis.
To achieve this purpose we studied 30 patients with CHF (27 males, mean age 57 years) undergoing CRT implantation.
The main finding of our study was that CRT exerted a substantial reduction in plasma BNP levels among responders, but no significant change in nonresponders after 3 months follow-up, only responders showed a significant decrease in plasma BNP levels (229.64 pg/ml ± 111) as compared to non-responders (468 pg/ml ± 96) P value <0.01. Response could be predicted with a cut-off value of 360 pg/ml, with a sensitivity and specificity of 90.9% and 87.5%, respectively.
In conclusion, BNP monitoring is potentially a good prognostic indicator of LV functional recovery and reverse remodeling after CRT can accurately identify echocardiographic responders after CRT. Percentage change in plasma BNP levels from baseline to 3 months was the strongest predictor of long-term response to CRT and may have potential to predict outcome. |
topic |
BNP CRT Heart failure |
url |
http://www.sciencedirect.com/science/article/pii/S2090730316300251 |
work_keys_str_mv |
AT amrnawar usefulnessofplasmabtypenatriureticpeptideasapredictortoidentifyrespondersfollowingcrt AT waelsamy usefulnessofplasmabtypenatriureticpeptideasapredictortoidentifyrespondersfollowingcrt AT hishamelaasar usefulnessofplasmabtypenatriureticpeptideasapredictortoidentifyrespondersfollowingcrt AT amalrizk usefulnessofplasmabtypenatriureticpeptideasapredictortoidentifyrespondersfollowingcrt AT sherifmokhtar usefulnessofplasmabtypenatriureticpeptideasapredictortoidentifyrespondersfollowingcrt |
_version_ |
1724867706267631616 |