S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic
S-adenosyl-L-homocysteine (SAH) hydrolases (SAHases) are involved in the regulation of methylation reactions in many organisms and are thus crucial for numerous cellular functions. Consequently, their dysregulation is associated with severe health problems. The SAHase-catalyzed reaction is reversibl...
Main Authors: | Lyn L. Kailing, Daniela Bertinetti, Caroline E. Paul, Tomasz Manszewski, Mariusz Jaskolski, Friedrich W. Herberg, Ioannis V. Pavlidis |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-03-01
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Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2018.00505/full |
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