A class frequency mixture model that adjusts for site-specific amino acid frequencies and improves inference of protein phylogeny

A class frequency mixture model that adjusts for site-specific amino acid frequencies and improves inference of protein phylogeny

<p>Abstract</p> <p>Background</p> <p>Widely used substitution models for proteins, such as the Jones-Taylor-Thornton (JTT) or Whelan and Goldman (WAG) models, are based on empirical amino acid interchange matrices estimated from databases of protein alignments that inco...

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Bibliographic Details
Main Authors: Li Karen, Wang Huai-Chun, Susko Edward, Roger Andrew J
Format: Article
Language:English
Published: BMC 2008-12-01
Series:BMC Evolutionary Biology
Online Access:http://www.biomedcentral.com/1471-2148/8/331

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