The role of Sirtuins in the study of eye diseases
In a variety of eye diseases, such as glaucoma, macular degeneration and other diseases, the occurrence of oxidative stress is very common, oxidative stress can cause cell damage and apoptosis. The Sirtuins family(histone class III deacetylases), as regulators of a variety of cells, is widely expres...
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Online Access: | http://ies.ijo.cn/cn_publish/2020/5/202005019.pdf |
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doaj-2fc8de3b5ee748b4911fe0271d6173e52020-11-25T03:21:44ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232020-05-0120583183310.3980/j.issn.1672-5123.2020.5.19The role of Sirtuins in the study of eye diseasesRong-Bin Liang<sup>*</sup>0Kang-Rui Wu<sup>*</sup>1Yi Shao2Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaCo-first anthors: Rong-Bin Liang and Kang-Rui Wu.Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaCo-first anthors: Rong-Bin Liang and Kang-Rui Wu.Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaCo-first anthors: Rong-Bin Liang and Kang-Rui Wu.In a variety of eye diseases, such as glaucoma, macular degeneration and other diseases, the occurrence of oxidative stress is very common, oxidative stress can cause cell damage and apoptosis. The Sirtuins family(histone class III deacetylases), as regulators of a variety of cells, is widely expressed in various organs of the human body. Homologous genes of sirtuins(SIRT1)are also widely expressed in the eyes, and their expression and activation can play an anti-oxidative stress role, prevent cell senescence and damage, and thus prevent the progression of disease. This paper discusses the mechanism and expression of Sirtuins family in glaucoma, senile macular degeneration, optic neuritis and senile cataract.http://ies.ijo.cn/cn_publish/2020/5/202005019.pdfsirtuinssirt1retinal ganglion cellsoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rong-Bin Liang<sup>*</sup> Kang-Rui Wu<sup>*</sup> Yi Shao |
spellingShingle |
Rong-Bin Liang<sup>*</sup> Kang-Rui Wu<sup>*</sup> Yi Shao The role of Sirtuins in the study of eye diseases Guoji Yanke Zazhi sirtuins sirt1 retinal ganglion cells oxidative stress |
author_facet |
Rong-Bin Liang<sup>*</sup> Kang-Rui Wu<sup>*</sup> Yi Shao |
author_sort |
Rong-Bin Liang<sup>*</sup> |
title |
The role of Sirtuins in the study of eye diseases |
title_short |
The role of Sirtuins in the study of eye diseases |
title_full |
The role of Sirtuins in the study of eye diseases |
title_fullStr |
The role of Sirtuins in the study of eye diseases |
title_full_unstemmed |
The role of Sirtuins in the study of eye diseases |
title_sort |
role of sirtuins in the study of eye diseases |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2020-05-01 |
description |
In a variety of eye diseases, such as glaucoma, macular degeneration and other diseases, the occurrence of oxidative stress is very common, oxidative stress can cause cell damage and apoptosis. The Sirtuins family(histone class III deacetylases), as regulators of a variety of cells, is widely expressed in various organs of the human body. Homologous genes of sirtuins(SIRT1)are also widely expressed in the eyes, and their expression and activation can play an anti-oxidative stress role, prevent cell senescence and damage, and thus prevent the progression of disease. This paper discusses the mechanism and expression of Sirtuins family in glaucoma, senile macular degeneration, optic neuritis and senile cataract. |
topic |
sirtuins sirt1 retinal ganglion cells oxidative stress |
url |
http://ies.ijo.cn/cn_publish/2020/5/202005019.pdf |
work_keys_str_mv |
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