A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain

A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain

Type IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin...

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Main Authors: Muneyoshi Okada, Hideyuki Yamawaki
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861318302202
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spelling doaj-2fcd0af8fb724e87920203f51d6aef8f2020-11-24T23:56:45ZengElsevierJournal of Pharmacological Sciences1347-86132019-02-0113925964A current perspective of canstatin, a fragment of type IV collagen alpha 2 chainMuneyoshi Okada0Hideyuki Yamawaki1Corresponding author. Fax: +81 176 23 8703.; Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada City, Aomori 034-8628, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada City, Aomori 034-8628, JapanType IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin has been widely investigated as a novel target molecule for cancer therapy. The anti-angiogenic effect of canstatin may be also useful for the treatment of ocular neovascularization. Recently, we have demonstrated that canstatin, which is abundantly expressed in the heart tissue, exerts various biological activities in cardiac cells. In rat H9c2 cardiomyoblasts, canstatin inhibits isoproterenol- or hypoxia-induced apoptosis. Canstatin plays an important role in modulating voltage-dependent calcium channel activity in rat cardiomyocytes. Canstatin also regulates various biological functions in rat cardiac fibroblasts and myofibroblasts. The expression of canstatin decreases in the infarcted area after myocardial infarction. This review focuses on a current perspective for the roles of canstatin in tumorigenesis, ocular neovascularization and cardiac pathology. Keywords: Anti-tumor effect, Canstatin, Fibroblasts, Cytoprotective effect, Myocardial infarctionhttp://www.sciencedirect.com/science/article/pii/S1347861318302202
collection DOAJ
language English
format Article
sources DOAJ
author Muneyoshi Okada
Hideyuki Yamawaki
spellingShingle Muneyoshi Okada
Hideyuki Yamawaki
A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain
Journal of Pharmacological Sciences
author_facet Muneyoshi Okada
Hideyuki Yamawaki
author_sort Muneyoshi Okada
title A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain
title_short A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain
title_full A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain
title_fullStr A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain
title_full_unstemmed A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain
title_sort current perspective of canstatin, a fragment of type iv collagen alpha 2 chain
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2019-02-01
description Type IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin has been widely investigated as a novel target molecule for cancer therapy. The anti-angiogenic effect of canstatin may be also useful for the treatment of ocular neovascularization. Recently, we have demonstrated that canstatin, which is abundantly expressed in the heart tissue, exerts various biological activities in cardiac cells. In rat H9c2 cardiomyoblasts, canstatin inhibits isoproterenol- or hypoxia-induced apoptosis. Canstatin plays an important role in modulating voltage-dependent calcium channel activity in rat cardiomyocytes. Canstatin also regulates various biological functions in rat cardiac fibroblasts and myofibroblasts. The expression of canstatin decreases in the infarcted area after myocardial infarction. This review focuses on a current perspective for the roles of canstatin in tumorigenesis, ocular neovascularization and cardiac pathology. Keywords: Anti-tumor effect, Canstatin, Fibroblasts, Cytoprotective effect, Myocardial infarction
url http://www.sciencedirect.com/science/article/pii/S1347861318302202
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