Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System

Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System

Cisplatin, a representative anticancer drug used to treat cancer, has many adverse effects. In particular, it causes significant damage to the kidneys. Thus, many researchers have studied the delivery of drugs, such as cisplatin, to cancer areas using targeted drug-delivery systems. Here, we propose...

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Main Authors: Myung Chul Lee, Shambhavi Pandey, Jae Woon Lim, Sangbae Park, Jae Eun Kim, Hyunmok Son, Jinsub Han, Hoon Seonwoo, Pankaj Garg, Jong Hoon Chung
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Applied Sciences
Subjects:
electrospray
anticancer treatment
cisplatin
drug delivery
cancer
Online Access:https://www.mdpi.com/2076-3417/11/7/3203
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spelling doaj-2fdc3c223c1844f69592052f105ce2b02021-04-02T23:06:06ZengMDPI AGApplied Sciences2076-34172021-04-01113203320310.3390/app11073203Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) SystemMyung Chul Lee0Shambhavi Pandey1Jae Woon Lim2Sangbae Park3Jae Eun Kim4Hyunmok Son5Jinsub Han6Hoon Seonwoo7Pankaj Garg8Jong Hoon Chung9Division of Engineering in Medicine Brigham and Women’s Hospital Department Harvard Medical School, Cambridge, MA 02139, USAResearch Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, KoreaDepartment of Biosystems & Biomaterial Science and Engineering, Seoul National University, Seoul 08826, KoreaDepartment of Biosystems & Biomaterial Science and Engineering, Seoul National University, Seoul 08826, KoreaDepartment of Biosystems Engineering, Seoul National University, Seoul 08826, KoreaDepartment of Biosystems & Biomaterial Science and Engineering, Seoul National University, Seoul 08826, KoreaDepartment of Biosystems Engineering, Seoul National University, Seoul 08826, KoreaDepartment of Industrial Machinery Engineering, College of Life Science and Natural Resources, Sunchon National University, Sunchon 57922, KoreaResearch Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, KoreaResearch Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, KoreaCisplatin, a representative anticancer drug used to treat cancer, has many adverse effects. In particular, it causes significant damage to the kidneys. Thus, many researchers have studied the delivery of drugs, such as cisplatin, to cancer areas using targeted drug-delivery systems. Here, we propose a new way to treat cancer by delivering anticancer drugs directly to the tumor site using the electrospray (ES) technique. We determined the optimal conditions for ES to promote the introduction of cisplatin into cancer cells. In our results, the group with cisplatin delivery-based electrospray (CDES) at 6 kV had an apoptosis of cancer cells approximately two times more than the group treated with cisplatin alone. We also confirmed that ES alone did not affect the survival of cells up to a voltage of 6 kV, but increased the permeability of the cell plasma membrane instantaneously, facilitating the influx of the drug.https://www.mdpi.com/2076-3417/11/7/3203electrosprayanticancer treatmentcisplatindrug deliverycancer
collection DOAJ
language English
format Article
sources DOAJ
author Myung Chul Lee
Shambhavi Pandey
Jae Woon Lim
Sangbae Park
Jae Eun Kim
Hyunmok Son
Jinsub Han
Hoon Seonwoo
Pankaj Garg
Jong Hoon Chung
spellingShingle Myung Chul Lee
Shambhavi Pandey
Jae Woon Lim
Sangbae Park
Jae Eun Kim
Hyunmok Son
Jinsub Han
Hoon Seonwoo
Pankaj Garg
Jong Hoon Chung
Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System
Applied Sciences
electrospray
anticancer treatment
cisplatin
drug delivery
cancer
author_facet Myung Chul Lee
Shambhavi Pandey
Jae Woon Lim
Sangbae Park
Jae Eun Kim
Hyunmok Son
Jinsub Han
Hoon Seonwoo
Pankaj Garg
Jong Hoon Chung
author_sort Myung Chul Lee
title Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System
title_short Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System
title_full Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System
title_fullStr Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System
title_full_unstemmed Induction of Apoptosis of Cancer Cells Using the Cisplatin Delivery Based Electrospray (CDES) System
title_sort induction of apoptosis of cancer cells using the cisplatin delivery based electrospray (cdes) system
publisher MDPI AG
series Applied Sciences
issn 2076-3417
publishDate 2021-04-01
description Cisplatin, a representative anticancer drug used to treat cancer, has many adverse effects. In particular, it causes significant damage to the kidneys. Thus, many researchers have studied the delivery of drugs, such as cisplatin, to cancer areas using targeted drug-delivery systems. Here, we propose a new way to treat cancer by delivering anticancer drugs directly to the tumor site using the electrospray (ES) technique. We determined the optimal conditions for ES to promote the introduction of cisplatin into cancer cells. In our results, the group with cisplatin delivery-based electrospray (CDES) at 6 kV had an apoptosis of cancer cells approximately two times more than the group treated with cisplatin alone. We also confirmed that ES alone did not affect the survival of cells up to a voltage of 6 kV, but increased the permeability of the cell plasma membrane instantaneously, facilitating the influx of the drug.
topic electrospray
anticancer treatment
cisplatin
drug delivery
cancer
url https://www.mdpi.com/2076-3417/11/7/3203
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AT shambhavipandey inductionofapoptosisofcancercellsusingthecisplatindeliverybasedelectrospraycdessystem
AT jaewoonlim inductionofapoptosisofcancercellsusingthecisplatindeliverybasedelectrospraycdessystem
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