Intracerebroventricular Administration of 192IgG-Saporin Alters Expression of Microglia-Associated Genes in the Dorsal But Not Ventral Hippocampus

Intracerebroventricular Administration of 192IgG-Saporin Alters Expression of Microglia-Associated Genes in the Dorsal But Not Ventral Hippocampus

One of important aspects of development of Alzheimer’s disease is degeneration of septal cholinergic neurons that innervate the hippocampus. We took advantage of widely used model of cholinergic deficit in the hippocampus, intracerebroventricular administration of 192IgG-saporin (Ig-saporin), to ana...

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Bibliographic Details
Main Authors: Yulia V. Dobryakova, Artem Kasianov, Maria I. Zaichenko, Mikhail Y. Stepanichev, Ekaterina A. Chesnokova, Petr M. Kolosov, Vladimir A. Markevich, Alexey P. Bolshakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
192IgG-saporin
RNA-seq
dorsal hippocampus
ventral hippocampus
microglia
rat
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00429/full

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