Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After Varicocelectomy
Purpose: Due to various reasons, spermatogenesis might not improve after varicocelectomy. Inhibin B, a sertoli cell glycoprotein, has proved itself as a marker of spermatogenesis. In this study, we measured serum level of inhibin B in patients with varicocele and through comparing pre and post opera...
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Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences
2010-05-01
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doaj-2fe2513b9239437788cc7992a4db2e272020-11-25T00:13:12ZengUrology and Nephrology Research Center, Shahid Beheshti University of Medical SciencesUrology Journal1735-13081735-546X2010-05-0172110114Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After VaricocelectomyMohammad Reza DadfarAkram AhangarpourAli Akbar HabibyDinyar KhazaelyPurpose: Due to various reasons, spermatogenesis might not improve after varicocelectomy. Inhibin B, a sertoli cell glycoprotein, has proved itself as a marker of spermatogenesis. In this study, we measured serum level of inhibin B in patients with varicocele and through comparing pre and post operativesemen analysis data, we tried to use serum level of inhibin B as a predictor of spermatogenetic improvement.Materials and Methods: This prospective clinical trial was carried out between September 2007 and September 2008 on 36 infertile men with high grade unilateral or bilateral varicocele. Scrotal ultrasonography and measurement of seminal parameters and serum level of inhibin B were performed for the patients and after confirmation of impaired spermatogenesis, they underwent a subinguinal nonmicroscopic varicocelectomy by a single surgeon. Physical examination, scrotal ultrasonography, and semen analysis were repeated at postoperative months of 3 and 6. Statistical data analysis was done by independent and paired sample t test and Spearman’s Rho test.Results: Mean size of the testis remained the same (P = .5), but mean sperm density, normal morphology, and motility all increased statistically significant after the operation (P < .05, P = .042, P = .023). A significant relationship was found between serum levels of inhibin B and the testis sperm count and morphology (P < .05), but not sperm motility (P > 0.05).Conclusion: It seems that serum level of inhibin B can be used as a reliable pre-operative marker of testicular potential activity and can also predict chance of spermatogenesis after varicocelectomy and save patients from useless surgical procedures.http://urologyjournal.org/index.php/uj/article/view/677/469varicocelespermatogenesissertoli cellsInhibin B |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Reza Dadfar Akram Ahangarpour Ali Akbar Habiby Dinyar Khazaely |
spellingShingle |
Mohammad Reza Dadfar Akram Ahangarpour Ali Akbar Habiby Dinyar Khazaely Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After Varicocelectomy Urology Journal varicocele spermatogenesis sertoli cells Inhibin B |
author_facet |
Mohammad Reza Dadfar Akram Ahangarpour Ali Akbar Habiby Dinyar Khazaely |
author_sort |
Mohammad Reza Dadfar |
title |
Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After Varicocelectomy |
title_short |
Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After Varicocelectomy |
title_full |
Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After Varicocelectomy |
title_fullStr |
Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After Varicocelectomy |
title_full_unstemmed |
Pre-operative Serum Level of Inhibin B as a Predictor of Spermatogenesis Improvement After Varicocelectomy |
title_sort |
pre-operative serum level of inhibin b as a predictor of spermatogenesis improvement after varicocelectomy |
publisher |
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences |
series |
Urology Journal |
issn |
1735-1308 1735-546X |
publishDate |
2010-05-01 |
description |
Purpose: Due to various reasons, spermatogenesis might not improve after varicocelectomy. Inhibin B, a sertoli cell glycoprotein, has proved itself as a marker of spermatogenesis. In this study, we measured serum level of inhibin B in patients with varicocele and through comparing pre and post operativesemen analysis data, we tried to use serum level of inhibin B as a predictor of spermatogenetic improvement.Materials and Methods: This prospective clinical trial was carried out between September 2007 and September 2008 on 36 infertile men with high grade unilateral or bilateral varicocele. Scrotal ultrasonography and measurement of seminal parameters and serum level of inhibin B were performed for the patients and after confirmation of impaired spermatogenesis, they underwent a subinguinal nonmicroscopic varicocelectomy by a single surgeon. Physical examination, scrotal ultrasonography, and semen analysis were repeated at postoperative months of 3 and 6. Statistical data analysis was done by independent and paired sample t test and Spearman’s Rho test.Results: Mean size of the testis remained the same (P = .5), but mean sperm density, normal morphology, and motility all increased statistically significant after the operation (P < .05, P = .042, P = .023). A significant relationship was found between serum levels of inhibin B and the testis sperm count and morphology (P < .05), but not sperm motility (P > 0.05).Conclusion: It seems that serum level of inhibin B can be used as a reliable pre-operative marker of testicular potential activity and can also predict chance of spermatogenesis after varicocelectomy and save patients from useless surgical procedures. |
topic |
varicocele spermatogenesis sertoli cells Inhibin B |
url |
http://urologyjournal.org/index.php/uj/article/view/677/469 |
work_keys_str_mv |
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