Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes

• Main Authors: Pranati L. Panuganti, Stefanie N. Hinkle, Shristi Rawal, Louise G. Grunnet, Yuan Lin, Aiyi Liu, Anne C. B. Thuesen, Sylvia H. Ley, Sjurdur F. Olesen, Cuilin Zhang
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: Nutrients
• Subjects: GDM; lactation; thyroid; triiodothyronine; thyroxine; thyroid antibodies
• Online Access: http://www.mdpi.com/2072-6643/10/7/938

Lactation is associated with reduced postpartum weight retention and a lower risk of several cardiometabolic disorders in population-based studies. We examined the association between lactation and long-term thyroid function among women with history of gestational diabetes mellitus (GDM), a high-risk population for subsequent metabolic complications. The study included 550 women who developed GDM in the Danish National Birth Cohort (1996–2002) and followed-up in the Diabetes & Women’s Health Study (2012–2014). We assessed adjusted associations between cumulative lactation duration and concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) measured at follow-up. Women with longer cumulative lactation duration tended to have higher fT3 levels (adjusted β and 95% confidence interval (CI) for ≥12 months vs. none: 0.19 (0.03–0.36); p-trend = 0.05). When restricted to women with a single lifetime pregnancy to control for parity (n = 70), women who lactated for >6 months (vs. none) had higher fT3 levels (0.46 pmol/L (0.12–0.80); p-trend = 0.02) and a higher fT3:fT4 ratio (0.61 (0.17–1.05); p-trend = 0.007). Our findings suggested that a longer duration of lactation may be related to greater serum fT3 levels and fT3:fT4 ratio 9–16 years postpartum among Danish women with a history of GDM. The association was particularly pronounced among women who only had one lifetime pregnancy.