Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01915-7 |
| Summary: | Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment and thus could serve to recalibrate the dysfunctional circuitry generating PD symptoms. |
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| ISSN: | 2399-3642 |