Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS t...

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Main Authors: Musa Ozturk, Ashwin Viswanathan, Sameer A. Sheth, Nuri F. Ince
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01915-7
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spelling doaj-2fe9844fb7e24824ab4e11d4efe3b96e2021-03-28T11:24:27ZengNature Publishing GroupCommunications Biology2399-36422021-03-014111410.1038/s42003-021-01915-7Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s diseaseMusa Ozturk0Ashwin Viswanathan1Sameer A. Sheth2Nuri F. Ince3Department of Biomedical Engineering, University of HoustonDepartment of Neurosurgery, Baylor College of MedicineDepartment of Neurosurgery, Baylor College of MedicineDepartment of Biomedical Engineering, University of HoustonOzturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment and thus could serve to recalibrate the dysfunctional circuitry generating PD symptoms.https://doi.org/10.1038/s42003-021-01915-7
collection DOAJ
language English
format Article
sources DOAJ
author Musa Ozturk
Ashwin Viswanathan
Sameer A. Sheth
Nuri F. Ince
spellingShingle Musa Ozturk
Ashwin Viswanathan
Sameer A. Sheth
Nuri F. Ince
Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
Communications Biology
author_facet Musa Ozturk
Ashwin Viswanathan
Sameer A. Sheth
Nuri F. Ince
author_sort Musa Ozturk
title Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_short Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_full Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_fullStr Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_full_unstemmed Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_sort electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in parkinson’s disease
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-03-01
description Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment and thus could serve to recalibrate the dysfunctional circuitry generating PD symptoms.
url https://doi.org/10.1038/s42003-021-01915-7
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AT ashwinviswanathan electroceuticallyinducedsubthalamichighfrequencyoscillationsandevokedcompoundactivitymayexplainthemechanismoftherapeuticstimulationinparkinsonsdisease
AT sameerasheth electroceuticallyinducedsubthalamichighfrequencyoscillationsandevokedcompoundactivitymayexplainthemechanismoftherapeuticstimulationinparkinsonsdisease
AT nurifince electroceuticallyinducedsubthalamichighfrequencyoscillationsandevokedcompoundactivitymayexplainthemechanismoftherapeuticstimulationinparkinsonsdisease
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