Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy
<b>Objective: </b> To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence (WB-DWI) to determine the peritoneal cancer index (PCI) in correlation with surgical and histopathological findings.<b>Methods: </b> Twenty-seven patients underwent preope...
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China Anti-Cancer Association
2018-06-01
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doaj-2febf4342efb407abdfbc2013720b7932020-11-25T01:13:25ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412018-06-0115216517010.20892/j.issn.2095-3941.2017.01622017000162Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancyHuan ZhangWeixing DaiCaixia Fu0Xu Yan1Alto Stemmer2Tong Tong3Guoxiang Cai4Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen 518000, China;MR Collaboration NE Asia, Siemens Healthcare, Shanghai 210318, China;MR Applications Development, Siemens Healthcare, Erlangen 91052, GermanyDepartment of Radiology;Department of Colorectal Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;<b>Objective: </b> To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence (WB-DWI) to determine the peritoneal cancer index (PCI) in correlation with surgical and histopathological findings.<b>Methods: </b> Twenty-seven patients underwent preoperative WB-MRI, followed by cytoreductive surgery for primary tumors of the appendix (<i>n</i> = 15), colorectum (<i>n</i> = 12), and associated peritoneal disease. A total of 351 regions were retrospectively reviewed. The sensitivity, specificity, and accuracy were calculated at 13 anatomical sites. The WB-DWI PCI and PCI type were compared with surgical and histopathological findings.<b>Results: </b> No statistical difference was found between the WB-DWI PCI and surgical PCI (<i>P</i> = 0.574). WB-DWI correctly predicted the PCI type in 24 of 27 patients with high accuracy (88.9%), including 10 of 10 patients with small-volume tumor, 12 of 14 with moderate-volume tumor, and 2 of 3 with large-volume tumor. WB-DWI correctly depicted tumors in 163 of 203 regions, with 40 false-negative and 23 false-positive regions. The overall sensitivity, specificity, and accuracy of WB-DWI for the detection of peritoneal tumors were 80.3%, 84.5%, and 82.1%, respectively. For lesions < 0.5 cm in diameter, WB-DWI demonstrated good sensitivity (69.4%).<b>Conclusions: </b> WB-DWI accurately predicted PCI before surgery in patients undergoing evaluation for cytoreductive surgery.http://www.cancerbiomed.org/index.php/cocr/article/view/1131MRIdiffusion-weighted imagingperitoneal cancer indexperitoneal metastasescolorectal malignancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huan Zhang Weixing Dai Caixia Fu Xu Yan Alto Stemmer Tong Tong Guoxiang Cai |
spellingShingle |
Huan Zhang Weixing Dai Caixia Fu Xu Yan Alto Stemmer Tong Tong Guoxiang Cai Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy Cancer Biology & Medicine MRI diffusion-weighted imaging peritoneal cancer index peritoneal metastases colorectal malignancy |
author_facet |
Huan Zhang Weixing Dai Caixia Fu Xu Yan Alto Stemmer Tong Tong Guoxiang Cai |
author_sort |
Huan Zhang |
title |
Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy |
title_short |
Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy |
title_full |
Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy |
title_fullStr |
Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy |
title_full_unstemmed |
Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy |
title_sort |
diagnostic value of whole-body mri with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy |
publisher |
China Anti-Cancer Association |
series |
Cancer Biology & Medicine |
issn |
2095-3941 2095-3941 |
publishDate |
2018-06-01 |
description |
<b>Objective: </b> To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence (WB-DWI) to determine the peritoneal cancer index (PCI) in correlation with surgical and histopathological findings.<b>Methods: </b> Twenty-seven patients underwent preoperative WB-MRI, followed by cytoreductive surgery for primary tumors of the appendix (<i>n</i> = 15), colorectum (<i>n</i> = 12), and associated peritoneal disease. A total of 351 regions were retrospectively reviewed. The sensitivity, specificity, and accuracy were calculated at 13 anatomical sites. The WB-DWI PCI and PCI type were compared with surgical and histopathological findings.<b>Results: </b> No statistical difference was found between the WB-DWI PCI and surgical PCI (<i>P</i> = 0.574). WB-DWI correctly predicted the PCI type in 24 of 27 patients with high accuracy (88.9%), including 10 of 10 patients with small-volume tumor, 12 of 14 with moderate-volume tumor, and 2 of 3 with large-volume tumor. WB-DWI correctly depicted tumors in 163 of 203 regions, with 40 false-negative and 23 false-positive regions. The overall sensitivity, specificity, and accuracy of WB-DWI for the detection of peritoneal tumors were 80.3%, 84.5%, and 82.1%, respectively. For lesions < 0.5 cm in diameter, WB-DWI demonstrated good sensitivity (69.4%).<b>Conclusions: </b> WB-DWI accurately predicted PCI before surgery in patients undergoing evaluation for cytoreductive surgery. |
topic |
MRI diffusion-weighted imaging peritoneal cancer index peritoneal metastases colorectal malignancy |
url |
http://www.cancerbiomed.org/index.php/cocr/article/view/1131 |
work_keys_str_mv |
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