Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory

Summary: Impaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical for social interaction and fear memory, as a model...

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Main Authors: Tzyy-Nan Huang, Tsan-Ting Hsu, Ming-Hui Lin, Hsiu-Chun Chuang, Hsiao-Tang Hu, Cheng-Pu Sun, Mi-Hua Tao, John Y. Lin, Yi-Ping Hsueh
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719311374
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spelling doaj-2ff79722249e40269b089631aef4f2e12020-11-25T01:34:57ZengElsevierCell Reports2211-12472019-10-012913448.e4Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and MemoryTzyy-Nan Huang0Tsan-Ting Hsu1Ming-Hui Lin2Hsiu-Chun Chuang3Hsiao-Tang Hu4Cheng-Pu Sun5Mi-Hua Tao6John Y. Lin7Yi-Ping Hsueh8Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROCInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROCInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROCInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROCInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROCInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, ROCInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, ROCSchool of Medicine, University of Tasmania, TAS 7000, AustraliaInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROC; Corresponding authorSummary: Impaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical for social interaction and fear memory, as a model to demonstrate that contralateral connectivity intensifies the synaptic response of basolateral amygdalae (BLA) and regulates amygdala-dependent behaviors. Retrograde tracing and c-FOS expression indicate that contralateral afferents widely innervate BLA non-randomly and that some BLA neurons innervate both contralateral BLA and the ipsilateral central amygdala (CeA). Our optogenetic and electrophysiological studies further suggest that contralateral BLA input results in the synaptic facilitation of BLA neurons, thereby intensifying the responses to cortical and thalamic stimulations. Finally, pharmacological inhibition and chemogenetic disconnection demonstrate that BLA contralateral facilitation is required for social interaction and memory. Our study suggests that interhemispheric connectivity potentiates the synaptic dynamics of BLA neurons and is critical for the full activation and functionality of amygdalae. : Huang et al. show that contralateral innervation between two basolateral amygdalae (BLA) in the two brain hemispheres evokes the synaptic activity of BLA and intensifies the BLA response to ipsilateral afferents, including cortical and thalamic inputs. BLA contralateral connectivity is required for amygdala-dependent behaviors, including social interaction and memory. Keywords: amygdala, anterior commissure, associative memory, contralateral innervation, social interaction, synaptic facilitationhttp://www.sciencedirect.com/science/article/pii/S2211124719311374
collection DOAJ
language English
format Article
sources DOAJ
author Tzyy-Nan Huang
Tsan-Ting Hsu
Ming-Hui Lin
Hsiu-Chun Chuang
Hsiao-Tang Hu
Cheng-Pu Sun
Mi-Hua Tao
John Y. Lin
Yi-Ping Hsueh
spellingShingle Tzyy-Nan Huang
Tsan-Ting Hsu
Ming-Hui Lin
Hsiu-Chun Chuang
Hsiao-Tang Hu
Cheng-Pu Sun
Mi-Hua Tao
John Y. Lin
Yi-Ping Hsueh
Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory
Cell Reports
author_facet Tzyy-Nan Huang
Tsan-Ting Hsu
Ming-Hui Lin
Hsiu-Chun Chuang
Hsiao-Tang Hu
Cheng-Pu Sun
Mi-Hua Tao
John Y. Lin
Yi-Ping Hsueh
author_sort Tzyy-Nan Huang
title Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory
title_short Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory
title_full Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory
title_fullStr Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory
title_full_unstemmed Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory
title_sort interhemispheric connectivity potentiates the basolateral amygdalae and regulates social interaction and memory
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2019-10-01
description Summary: Impaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical for social interaction and fear memory, as a model to demonstrate that contralateral connectivity intensifies the synaptic response of basolateral amygdalae (BLA) and regulates amygdala-dependent behaviors. Retrograde tracing and c-FOS expression indicate that contralateral afferents widely innervate BLA non-randomly and that some BLA neurons innervate both contralateral BLA and the ipsilateral central amygdala (CeA). Our optogenetic and electrophysiological studies further suggest that contralateral BLA input results in the synaptic facilitation of BLA neurons, thereby intensifying the responses to cortical and thalamic stimulations. Finally, pharmacological inhibition and chemogenetic disconnection demonstrate that BLA contralateral facilitation is required for social interaction and memory. Our study suggests that interhemispheric connectivity potentiates the synaptic dynamics of BLA neurons and is critical for the full activation and functionality of amygdalae. : Huang et al. show that contralateral innervation between two basolateral amygdalae (BLA) in the two brain hemispheres evokes the synaptic activity of BLA and intensifies the BLA response to ipsilateral afferents, including cortical and thalamic inputs. BLA contralateral connectivity is required for amygdala-dependent behaviors, including social interaction and memory. Keywords: amygdala, anterior commissure, associative memory, contralateral innervation, social interaction, synaptic facilitation
url http://www.sciencedirect.com/science/article/pii/S2211124719311374
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