Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms10857 |
Summary: | The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma. |
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ISSN: | 2041-1723 |