Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection
Aim To determine clinical prognostic factors and their impact on the risk of recurrence of newly discovered non-muscle-invasive bladder cancer. Methods The study included 120 patients of both sexes aged 45-80 years with newly discovered non-muscle-invasive bladder cancer. All the patients were tr...
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doaj-3005edbae52848f7898db250d420f8c12020-11-24T23:25:18ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452016-02-01131566110.17392/824-16Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resectionHaris Ðug0Samed Jagodić1Jasmina Ahmetović-Ðug2Zijad Selimović3Alemdar Sulejmanović4Department of Urology, Clinic of Surgery, University Clinical Centre of Tuzla; Tuzla, Bosnia and HerzegovinaDepartment of Urology, Clinic of Surgery, University Clinical Centre of Tuzla; Tuzla, Bosnia and HerzegovinaClinic of Anesthesiology and Reanimation, University Clinical Centre of Tuzla; Tuzla, Bosnia and HerzegovinaDepartment of Urology, Clinic of Surgery, University Clinical Centre of Tuzla; Tuzla, Bosnia and HerzegovinaDepartment of Urology, Clinic of Surgery, University Clinical Centre of Tuzla; Tuzla, Bosnia and HerzegovinaAim To determine clinical prognostic factors and their impact on the risk of recurrence of newly discovered non-muscle-invasive bladder cancer. Methods The study included 120 patients of both sexes aged 45-80 years with newly discovered non-muscle-invasive bladder cancer. All the patients were treated surgically by transurethral electro resection (TUER). The outcome of patients with and without recurrence was followed at intervals of three months after surgery, the total of two years. For monitoring the probability of early recurrence the criteria of the European Organization for Research and Treatment of Cancer (EORTC) were used. Results The average age of the patients was 65.9 years, 79 (79.2%) males and 21 (20.8%) females. The total of 67 (55.8%) patients had a recurrence during the period of monitoring. The average time to the first and fourth recurrence was 15.4 and 23.9 months, respectively. Numbers of tumors and a degree of invasion had a significant prognostic impact on the risk of recurrence. The EORTC score was a highly significant predictor of recurrence (OR=1.237; p<0.001). Conclusion Based on available clinical and pathological prognostic factors and by stratification of patients into three disease risk groups it is possible to predict the possibility of disease. Individual approach and recommendations for the treatment using EORTC risk tables should improve the quality of treatment.http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/02%20Djug%20824%20A.pdfimmunotherapyprobabilitytreatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haris Ðug Samed Jagodić Jasmina Ahmetović-Ðug Zijad Selimović Alemdar Sulejmanović |
spellingShingle |
Haris Ðug Samed Jagodić Jasmina Ahmetović-Ðug Zijad Selimović Alemdar Sulejmanović Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection Medicinski Glasnik immunotherapy probability treatment |
author_facet |
Haris Ðug Samed Jagodić Jasmina Ahmetović-Ðug Zijad Selimović Alemdar Sulejmanović |
author_sort |
Haris Ðug |
title |
Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection |
title_short |
Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection |
title_full |
Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection |
title_fullStr |
Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection |
title_full_unstemmed |
Predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection |
title_sort |
predicting recurrence of non-muscle-invasive bladder cancer after transurethral resection |
publisher |
Medical Association of Zenica-Doboj Canton |
series |
Medicinski Glasnik |
issn |
1840-0132 1840-2445 |
publishDate |
2016-02-01 |
description |
Aim To determine clinical prognostic factors and their impact on the risk of recurrence of newly discovered non-muscle-invasive bladder cancer.
Methods The study included 120 patients of both sexes aged 45-80 years with newly discovered non-muscle-invasive bladder cancer. All the patients were treated surgically by transurethral electro resection (TUER). The outcome of patients with and without recurrence was followed at intervals of three months after surgery, the total of two years. For monitoring the probability of early recurrence the criteria of the European Organization for Research and Treatment of Cancer (EORTC) were used.
Results The average age of the patients was 65.9 years, 79 (79.2%) males and 21 (20.8%) females. The total of 67 (55.8%) patients had a recurrence during the period of monitoring. The average time to the first and fourth recurrence was 15.4 and 23.9 months, respectively. Numbers of tumors and a degree of invasion had a significant prognostic impact on the risk of recurrence. The EORTC score was a highly significant predictor of recurrence (OR=1.237; p<0.001).
Conclusion Based on available clinical and pathological prognostic factors and by stratification of patients into three disease risk groups it is possible to predict the possibility of disease. Individual approach and recommendations for the treatment using EORTC risk tables should improve the quality of treatment. |
topic |
immunotherapy probability treatment |
url |
http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/02%20Djug%20824%20A.pdf |
work_keys_str_mv |
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