Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate
Novel biomedical composites, based on organically modified vermiculite and montmorillonite with deposited Ca-deficient hydroxyapatite (CDH), were prepared. The monoionic sodium forms of vermiculite and montmorillonite were intercalated with chlorhexidine diacetate (CA). The surfaces of organoclays w...
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doaj-300f3526864d4e18941c2ab7195582052020-11-24T20:53:43ZengMDPI AGMaterials1996-19442019-09-011218299610.3390/ma12182996ma12182996Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay SubstrateLenka Pazourková0Magda Reli1Marianna Hundáková2Erich Pazdziora3Daniela Predoi4Gražyna Simha Martynková5Khalid Lafdi6IT4Innovations Centre of Excellence, VŠB–Technical University of Ostrava, 17.listopadu 15/2172, 708 33 Ostrava–Poruba, Czech RepublicNanotechnology Centre, VŠB–Technical University of Ostrava, 17.listopadu 15/2172, 708 33 Ostrava–Poruba, Czech RepublicNanotechnology Centre, VŠB–Technical University of Ostrava, 17.listopadu 15/2172, 708 33 Ostrava–Poruba, Czech RepublicInstitute of Public Health Ostrava, Centre of Clinical Laboratories, Partyzánské náměstí 7, 702 00 Ostrava, Czech RepublicNational Institute of Materials Physics, P.O. Box MG 07, 077125 Magurele, RomaniaIT4Innovations Centre of Excellence, VŠB–Technical University of Ostrava, 17.listopadu 15/2172, 708 33 Ostrava–Poruba, Czech RepublicUniversity of Dayton, 300 College Park, Dayton, OH 45469, USANovel biomedical composites, based on organically modified vermiculite and montmorillonite with deposited Ca-deficient hydroxyapatite (CDH), were prepared. The monoionic sodium forms of vermiculite and montmorillonite were intercalated with chlorhexidine diacetate (CA). The surfaces of organoclays were used for the precipitation of Ca-deficient hydroxyapatite. The composites with Ca-deficient hydroxyapatite showed very good antibacterial effects, similar to the antimicrobial activity of pure organoclay samples. Better antibacterial activity was shown in the organically modified montmorillonite sample with Ca-deficient hydroxyapatite compared with the vermiculite composite, but, in the case of <i>Staphylococcus aureus</i>, both composites showed the same minimum inhibitory concentration (MIC) value. The antimicrobial effect of composites against bacteria and fungi increased with the time of exposure. The structural characterization of all the prepared materials, performed using X-ray diffraction and FT infrared spectroscopy analysis, detected no changes in the original clay or CDH during the intercalation or precipitation process, therefore we expect the strength of the compounds to be in the original power.https://www.mdpi.com/1996-1944/12/18/2996Ca-deficient hydroxyapatitechlorhexidineorganoclayantimicrobial effect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lenka Pazourková Magda Reli Marianna Hundáková Erich Pazdziora Daniela Predoi Gražyna Simha Martynková Khalid Lafdi |
spellingShingle |
Lenka Pazourková Magda Reli Marianna Hundáková Erich Pazdziora Daniela Predoi Gražyna Simha Martynková Khalid Lafdi Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate Materials Ca-deficient hydroxyapatite chlorhexidine organoclay antimicrobial effect |
author_facet |
Lenka Pazourková Magda Reli Marianna Hundáková Erich Pazdziora Daniela Predoi Gražyna Simha Martynková Khalid Lafdi |
author_sort |
Lenka Pazourková |
title |
Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate |
title_short |
Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate |
title_full |
Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate |
title_fullStr |
Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate |
title_full_unstemmed |
Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate |
title_sort |
study of the structure and antimicrobial activity of ca-deficient ceramics on chlorhexidine nanoclay substrate |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2019-09-01 |
description |
Novel biomedical composites, based on organically modified vermiculite and montmorillonite with deposited Ca-deficient hydroxyapatite (CDH), were prepared. The monoionic sodium forms of vermiculite and montmorillonite were intercalated with chlorhexidine diacetate (CA). The surfaces of organoclays were used for the precipitation of Ca-deficient hydroxyapatite. The composites with Ca-deficient hydroxyapatite showed very good antibacterial effects, similar to the antimicrobial activity of pure organoclay samples. Better antibacterial activity was shown in the organically modified montmorillonite sample with Ca-deficient hydroxyapatite compared with the vermiculite composite, but, in the case of <i>Staphylococcus aureus</i>, both composites showed the same minimum inhibitory concentration (MIC) value. The antimicrobial effect of composites against bacteria and fungi increased with the time of exposure. The structural characterization of all the prepared materials, performed using X-ray diffraction and FT infrared spectroscopy analysis, detected no changes in the original clay or CDH during the intercalation or precipitation process, therefore we expect the strength of the compounds to be in the original power. |
topic |
Ca-deficient hydroxyapatite chlorhexidine organoclay antimicrobial effect |
url |
https://www.mdpi.com/1996-1944/12/18/2996 |
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