Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives

As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy an...

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Main Authors:	X Tang, L Fan, M Pei, L Zeng, Z Ge
Format:	Article
Language:	English
Published:	AO Research Institute Davos 2015-07-01
Series:	European Cells & Materials
Subjects:	Chondrogenic differentiation chondrogenesis mesenchymal stem cells chondrocytes chondrogenic differentiation factors.
Online Access:	http://www.ecmjournal.org/papers/vol030/pdf/v030a02.pdf

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spelling	doaj-301689d544004c5882efb847e107a6502020-11-25T01:54:08Zeng AO Research Institute DavosEuropean Cells & Materials1473-22622015-07-0130122710.22203/eCM.v030a02Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectivesX TangL Fan M PeiL ZengZ Ge0Department of Biomedical Engineering, College of Engineering, Peking University, P.R China, 100871As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy and subsequent endochondral ossification. In this review, we examine the history of currently established protocols of chondrogenic differentiation and elaborate on the roles of individual components of chondrogenic differentiation medium. We also summarise the effects of physical, chemical and biological factors involved, and propose potential strategies to differentiate MSCs into articular chondrocytes with homogenous mature phenotypes through spatial-temporal incorporation of cell differentiation and chondrogenesis.http://www.ecmjournal.org/papers/vol030/pdf/v030a02.pdfChondrogenic differentiationchondrogenesismesenchymal stem cellschondrocyteschondrogenic differentiation factors.
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	X Tang L Fan M Pei L Zeng Z Ge
spellingShingle	X Tang L Fan M Pei L Zeng Z Ge Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives European Cells & Materials Chondrogenic differentiation chondrogenesis mesenchymal stem cells chondrocytes chondrogenic differentiation factors.
author_facet	X Tang L Fan M Pei L Zeng Z Ge
author_sort	X Tang
title	Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives
title_short	Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives
title_full	Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives
title_fullStr	Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives
title_full_unstemmed	Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives
title_sort	evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives
publisher	AO Research Institute Davos
series	European Cells & Materials
issn	1473-2262
publishDate	2015-07-01
description	As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy and subsequent endochondral ossification. In this review, we examine the history of currently established protocols of chondrogenic differentiation and elaborate on the roles of individual components of chondrogenic differentiation medium. We also summarise the effects of physical, chemical and biological factors involved, and propose potential strategies to differentiate MSCs into articular chondrocytes with homogenous mature phenotypes through spatial-temporal incorporation of cell differentiation and chondrogenesis.
topic	Chondrogenic differentiation chondrogenesis mesenchymal stem cells chondrocytes chondrogenic differentiation factors.
url	http://www.ecmjournal.org/papers/vol030/pdf/v030a02.pdf
work_keys_str_mv	AT xtang evolvingconceptsofchondrogenicdifferentiationhistorystateoftheartandfutureperspectives AT lfan evolvingconceptsofchondrogenicdifferentiationhistorystateoftheartandfutureperspectives AT mpei evolvingconceptsofchondrogenicdifferentiationhistorystateoftheartandfutureperspectives AT lzeng evolvingconceptsofchondrogenicdifferentiationhistorystateoftheartandfutureperspectives AT zge evolvingconceptsofchondrogenicdifferentiationhistorystateoftheartandfutureperspectives
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Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives

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