Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features.

Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features.

The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to investigate how VRC01 prevention efficacy (PE) varies with HIV-1 envelope (Env) amin...

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Bibliographic Details
Main Authors: Craig A Magaret, David C Benkeser, Brian D Williamson, Bhavesh R Borate, Lindsay N Carpp, Ivelin S Georgiev, Ian Setliff, Adam S Dingens, Noah Simon, Marco Carone, Christopher Simpkins, David Montefiori, Galit Alter, Wen-Han Yu, Michal Juraska, Paul T Edlefsen, Shelly Karuna, Nyaradzo M Mgodi, Srilatha Edugupanti, Peter B Gilbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC6459550?pdf=render

Internet

http://europepmc.org/articles/PMC6459550?pdf=render

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