Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7
Atherosclerosis is the leading cause of vascular disease worldwide and contributes significantly to deaths from cardiovascular complications. There is a remarkably close relationship between atherosclerotic plaque formation and the activation of renin-angiotensin system (RAS). However, depending on...
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doaj-301b61abcb284752a5ddb4b165aacc222020-11-25T03:40:43ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-09-011110.3389/fphys.2020.01067566941Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7Gabriela M. Silva0Maria S. França-Falcão1Natália Tabosa M. Calzerra2Mickael S. Luz3Danilo Duarte A. Gadelha4Camille M. Balarini5Thyago M. Queiroz6Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vitória de Santo Antão, BrazilCenter of Biotechnology, Federal University of Paraiba, João Pessoa, BrazilParaiba Higher Education Institute, IESP, Cabedelo, BrazilCenter of Biotechnology, Federal University of Paraiba, João Pessoa, BrazilHealth Sciences Center, Federal University of Paraiba, João Pessoa, BrazilHealth Sciences Center, Federal University of Paraiba, João Pessoa, BrazilLaboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vitória de Santo Antão, BrazilAtherosclerosis is the leading cause of vascular disease worldwide and contributes significantly to deaths from cardiovascular complications. There is a remarkably close relationship between atherosclerotic plaque formation and the activation of renin-angiotensin system (RAS). However, depending on which RAS pathway is activated, pro‐ or anti-atherogenic outcomes may be observed. This brief review focuses on the role of three of the most important pieces of RAS axis, angiotensin II (Ang-II), angiotensin converting enzyme type 2 (ACE2), and angiotensin 1–7 (Ang-1–7) and their involvement in atherosclerosis. We focused on the effects of these molecules on vascular function and inflammation, which are important determinants of atherogenesis. Furthermore, we highlighted potential pharmacological approaches to treat this disorder.https://www.frontiersin.org/article/10.3389/fphys.2020.01067/fullangiotensin converting enzyme type 2angiotensin IIangiotensin 1–7atherosclerosisendothelial dysfunctioninflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gabriela M. Silva Maria S. França-Falcão Natália Tabosa M. Calzerra Mickael S. Luz Danilo Duarte A. Gadelha Camille M. Balarini Thyago M. Queiroz |
spellingShingle |
Gabriela M. Silva Maria S. França-Falcão Natália Tabosa M. Calzerra Mickael S. Luz Danilo Duarte A. Gadelha Camille M. Balarini Thyago M. Queiroz Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7 Frontiers in Physiology angiotensin converting enzyme type 2 angiotensin II angiotensin 1–7 atherosclerosis endothelial dysfunction inflammation |
author_facet |
Gabriela M. Silva Maria S. França-Falcão Natália Tabosa M. Calzerra Mickael S. Luz Danilo Duarte A. Gadelha Camille M. Balarini Thyago M. Queiroz |
author_sort |
Gabriela M. Silva |
title |
Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7 |
title_short |
Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7 |
title_full |
Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7 |
title_fullStr |
Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7 |
title_full_unstemmed |
Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7 |
title_sort |
role of renin-angiotensin system components in atherosclerosis: focus on ang-ii, ace2, and ang-1–7 |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-09-01 |
description |
Atherosclerosis is the leading cause of vascular disease worldwide and contributes significantly to deaths from cardiovascular complications. There is a remarkably close relationship between atherosclerotic plaque formation and the activation of renin-angiotensin system (RAS). However, depending on which RAS pathway is activated, pro‐ or anti-atherogenic outcomes may be observed. This brief review focuses on the role of three of the most important pieces of RAS axis, angiotensin II (Ang-II), angiotensin converting enzyme type 2 (ACE2), and angiotensin 1–7 (Ang-1–7) and their involvement in atherosclerosis. We focused on the effects of these molecules on vascular function and inflammation, which are important determinants of atherogenesis. Furthermore, we highlighted potential pharmacological approaches to treat this disorder. |
topic |
angiotensin converting enzyme type 2 angiotensin II angiotensin 1–7 atherosclerosis endothelial dysfunction inflammation |
url |
https://www.frontiersin.org/article/10.3389/fphys.2020.01067/full |
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