Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infection.

Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infection.

A single correlate of effective vaccine protection against chronic HCV infection has yet to be defined. In this study, we analyzed T-cell responses in four chimpanzees, immunized with core-E1-E2-NS3 and subsequently infected with HCV1b. Viral clearance was observed in one animal, while the other thr...

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Bibliographic Details
Main Authors: Babs E Verstrepen, Ernst J Verschoor, Zahra C Fagrouch, Petra Mooij, Natasja G de Groot, Ronald E Bontrop, Willy M Bogers, Jonathan L Heeney, Gerrit Koopman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3989318?pdf=render

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