Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review
Xutong Li,1 Jie Chai,1 Zhi Wang,2 Lin Lu,1 Qingye Zhao,1 Jie Zhou,1 Fang Ju1 1Department of Oncology, Second Affiliated Hospital, Qingdao University, Qingdao, Shandong 266042, People’s Republic of China; 2Department of MRI, Second Affiliated Hospital, Qingdao University, Qingdao, Shandong...
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doaj-301f8f4531f442b58421007c05ab29da2020-11-25T00:40:28ZengDove Medical PressOncoTargets and Therapy1178-69302018-07-01Volume 114407441139572Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature reviewLi XTChai JWang ZLu LZhao QYZhou JJu FXutong Li,1 Jie Chai,1 Zhi Wang,2 Lin Lu,1 Qingye Zhao,1 Jie Zhou,1 Fang Ju1 1Department of Oncology, Second Affiliated Hospital, Qingdao University, Qingdao, Shandong 266042, People’s Republic of China; 2Department of MRI, Second Affiliated Hospital, Qingdao University, Qingdao, Shandong 266042, People’s Republic of China Abstract: Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare clinical-radiologic syndrome. There are reports that RPLS may be associated with cancer therapy including some chemotherapy drugs and antiangiogenic drugs. This paper reported a case of RPLS induced by apatinib, a vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitor. A 47-year-old cervical cancer patient was administered apatinib, and 3 months later, headache, dizziness, blurred vision, and hypertension appeared. She was diagnosed with RPLS by nuclear magnetic resonance imaging (MRI). After apatinib discontinuation and normotensive treatment, her symptoms completely reversed. Antiangiogenic drugs potentially damage the balance of the blood–brain barrier by directly injuring vascular endothelial cells, resulting in the occurrence of RPLS. This case is the first report of RPLS induced by apatinib. Keywords: reversible posterior leukoencephalopathy syndrome, apatinib, antiangiogenesis, targeted therapyhttps://www.dovepress.com/reversible-posterior-leukoencephalopathy-syndrome-induced-by-apatinib--peer-reviewed-article-OTTreversible posterior leukoencephalopathy syndromeapatinibantiangiogenesistargeted therapy; |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li XT Chai J Wang Z Lu L Zhao QY Zhou J Ju F |
spellingShingle |
Li XT Chai J Wang Z Lu L Zhao QY Zhou J Ju F Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review OncoTargets and Therapy reversible posterior leukoencephalopathy syndrome apatinib antiangiogenesis targeted therapy; |
author_facet |
Li XT Chai J Wang Z Lu L Zhao QY Zhou J Ju F |
author_sort |
Li XT |
title |
Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review |
title_short |
Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review |
title_full |
Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review |
title_fullStr |
Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review |
title_full_unstemmed |
Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review |
title_sort |
reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2018-07-01 |
description |
Xutong Li,1 Jie Chai,1 Zhi Wang,2 Lin Lu,1 Qingye Zhao,1 Jie Zhou,1 Fang Ju1 1Department of Oncology, Second Affiliated Hospital, Qingdao University, Qingdao, Shandong 266042, People’s Republic of China; 2Department of MRI, Second Affiliated Hospital, Qingdao University, Qingdao, Shandong 266042, People’s Republic of China Abstract: Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare clinical-radiologic syndrome. There are reports that RPLS may be associated with cancer therapy including some chemotherapy drugs and antiangiogenic drugs. This paper reported a case of RPLS induced by apatinib, a vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitor. A 47-year-old cervical cancer patient was administered apatinib, and 3 months later, headache, dizziness, blurred vision, and hypertension appeared. She was diagnosed with RPLS by nuclear magnetic resonance imaging (MRI). After apatinib discontinuation and normotensive treatment, her symptoms completely reversed. Antiangiogenic drugs potentially damage the balance of the blood–brain barrier by directly injuring vascular endothelial cells, resulting in the occurrence of RPLS. This case is the first report of RPLS induced by apatinib. Keywords: reversible posterior leukoencephalopathy syndrome, apatinib, antiangiogenesis, targeted therapy |
topic |
reversible posterior leukoencephalopathy syndrome apatinib antiangiogenesis targeted therapy; |
url |
https://www.dovepress.com/reversible-posterior-leukoencephalopathy-syndrome-induced-by-apatinib--peer-reviewed-article-OTT |
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