3-(2-Aminoethyl)-2-[4-(trifluoromethoxy)anilino]quinazolin-4(3H)-one

• Main Authors: Zhao-Hui Cai, Xiao-Bao Chen, Xu-Hong Yang, Xiang Wang
• Format: Article
• Language: English
• Published: International Union of Crystallography 2010-07-01
• Series: Acta Crystallographica Section E
• Online Access: http://scripts.iucr.org/cgi-bin/paper?S1600536810024645

In the title compound, C17H15F3N4O2, the dihedral angle between the trifluoromethoxy-substituted benzene ring and the pyrimidinone ring is 45.1 (5)°, while that between the fused benzene ring and the pyrimidinone ring is 0.67 (1)°. Part of one of the benzene rings and its trifluoromethoxy substituent are disordered over two positions of approximately equal occupancy (0.51:0.49). Intermolecular N—H...O and N—H...N hydrogen bonds contribute to the stability of the crystal structure. A weak intramolecular C—H...F contact is also found. In addition, π–π stacking interactions, with centroid–centroid distances in the range 3.673 (6)–3.780 (8) Å, and weak C—H...π interactions are also observed.