MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta

MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta

O6-methylguanine DNA methyltransferase (MGMT), a DNA repair enzyme, has been reported in some congenital malformations, but it is less frequently reported in neural tube defects. This study investigated MGMT mRNA expression and methylation levels in the early embryo and in different embryonic stages...

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Bibliographic Details
Main Authors: He-Nan Zhang, Yi Guo, Wei Ma, Jia Xue, Wei-Lin Wang, Zheng-Wei Yuan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; neural tube defects; spina bifida aperta; spinal cord; all-trans retinoic acid; O6-methylguanine DNA methyl-transferase; gene expression; DNA methylation; promoter; bisulfite sequencing polymerase chain reaction; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=361;epage=368;aulast=Zhang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=361;epage=368;aulast=Zhang

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