RELATIONSHIP OF THE METABOLIC SYNDROME AND CORONARY ARTERY DISEASE IN PATIENTS WITH STABLE ANGINA

• Main Authors: Masoumeh Sadeghi, Hamid Saneie, Mohammad Garak-Yaraghi, Golnaz Rozati, HamidReza Roohafza, Mohammad Talaei
• Format: Article
• Language: English
• Published: Vesnu Publications 2010-12-01
• Series: ARYA Atherosclerosis
• Online Access: http://arya.mui.ac.ir/index.php/arya/article/view/129
• ISSN: 1735-3955; 2251-6638

Abstract<br />INTRODUCTION: In view of the high prevalence of coronary artery diseases (CAD)<br />and the fact that the metabolic syndrome is known to predispose to CAD, we studied the<br />relationship between various components of the metabolic syndrome and the severity of<br />CAD.<br />METHODS: A total of 545 patients with stable angina were included in this crosssectional<br />study. Questionnaires were used to obtain information on demographic<br />characteristics, drug history, and history of previous hospitalization. Blood pressure (BP)<br />and waist circumference (WC) were measured. Ten-hour fasting blood samples were<br />taken to measure blood sugar, high-density lipoprotein cholesterol (HDL-C), and<br />triglyceride (TG) using autoanalyzer. Angiography was performed with the standard<br />method and the patients were scored using extent scoring. The metabolic syndrome was<br />defined according to ATP-III. SPSS 11 was use to analyze data with t-test, ANOVA,<br />correlation and logistic regression tests.<br />RESULTS: The patients had a mean age of 57.93&plusmn;10.13 years. High HDL-C was the<br />most frequent abnormality, followed by increased WC and TG. Severity of metabolic<br />syndrome increased with age. CAD was detected in 78.9% of patients with the metabolic<br />syndrome and 46.7% of patients without it (P&lt;0.05). In regression analysis, the<br />metabolic syndrome was found to be a risk factor for CAD (OR=1.35, CI=1.13-1.60).<br />Direct correlation was found between angiography score and metabolic syndrome<br />(P&lt;0.01, r=0.15).<br />CONCLUSIONS: The metabolic syndrome is a predisposing factor to CAD; hence CAD<br />prevention should involve measures to control metabolic syndrome, especially through<br />lifestyle modification.<br />Key Words: Metabolic syndrome, CAD.