Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa
The alkaloids content, cytotoxicity activity and anti-parasitic activity of Tinospora crispa Miers and Psidium guajava L. against parasite Toxoplasma gondii were investigated. Both of the crude plant extracts contained high amount of crude alkaloids and were not toxic to Vero cells (EC50 >100 µg...
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Bangladesh Pharmacological Society
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doaj-30494ee92b684a31a78a38deeaef130c2020-11-25T00:23:15ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882012-11-017410.3329/bjp.v7i4.12499Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispaWei Cai Lee0Roziahanim Mahmud1Rahmah Noordin2Suthagar Pillai Piaru3Shanmugapriya Perumal4Sabariah Ismail5School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Pulau PinangSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Pulau PinangInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 Pulau PinangSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Pulau PinangSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Pulau PinangCentre For Drug Research, Universiti Sains Malaysia, 11800 Pulau Pinang The alkaloids content, cytotoxicity activity and anti-parasitic activity of Tinospora crispa Miers and Psidium guajava L. against parasite Toxoplasma gondii were investigated. Both of the crude plant extracts contained high amount of crude alkaloids and were not toxic to Vero cells (EC50 >100 µg/mL). Following non-toxicity finding of the extracts, the in vitro anti-parasitic assay was carried out with clindamycin served as the positive control. T. crispa stem crude extract with EC50 value of 7.71 ± 1.56 µg/mL, showed potential anti-T. gondii activity as the results were comparable to clindamycin (EC50 = 6.24 ± 0.53 µg/mL). These findings suggest that stem extract of T. crispa Miers contained some potential active compounds against Toxoplasma gondii. Selective important alkaloids in the T. crispa stem fractions may be the key factor for their anti-parasitic activity. Further study is being carried out to investigate for potential bioactives present in the T. crispa extract through bioactivity guided fractionation. https://www.banglajol.info/index.php/BJP/article/view/12499AlkaloidCytotoxicityIn vitro anti-Toxoplasma gondii assayPsidium guajavaTinospora crispa |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Cai Lee Roziahanim Mahmud Rahmah Noordin Suthagar Pillai Piaru Shanmugapriya Perumal Sabariah Ismail |
spellingShingle |
Wei Cai Lee Roziahanim Mahmud Rahmah Noordin Suthagar Pillai Piaru Shanmugapriya Perumal Sabariah Ismail Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa Bangladesh Journal of Pharmacology Alkaloid Cytotoxicity In vitro anti-Toxoplasma gondii assay Psidium guajava Tinospora crispa |
author_facet |
Wei Cai Lee Roziahanim Mahmud Rahmah Noordin Suthagar Pillai Piaru Shanmugapriya Perumal Sabariah Ismail |
author_sort |
Wei Cai Lee |
title |
Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa |
title_short |
Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa |
title_full |
Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa |
title_fullStr |
Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa |
title_full_unstemmed |
Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa |
title_sort |
alkaloids content, cytotoxicity and anti-toxoplasma gondii activity of psidium guajava l. and tinospora crispa |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-0088 |
publishDate |
2012-11-01 |
description |
The alkaloids content, cytotoxicity activity and anti-parasitic activity of Tinospora crispa Miers and Psidium guajava L. against parasite Toxoplasma gondii were investigated. Both of the crude plant extracts contained high amount of crude alkaloids and were not toxic to Vero cells (EC50 >100 µg/mL). Following non-toxicity finding of the extracts, the in vitro anti-parasitic assay was carried out with clindamycin served as the positive control. T. crispa stem crude extract with EC50 value of 7.71 ± 1.56 µg/mL, showed potential anti-T. gondii activity as the results were comparable to clindamycin (EC50 = 6.24 ± 0.53 µg/mL). These findings suggest that stem extract of T. crispa Miers contained some potential active compounds against Toxoplasma gondii. Selective important alkaloids in the T. crispa stem fractions may be the key factor for their anti-parasitic activity. Further study is being carried out to investigate for potential bioactives present in the T. crispa extract through bioactivity guided fractionation.
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topic |
Alkaloid Cytotoxicity In vitro anti-Toxoplasma gondii assay Psidium guajava Tinospora crispa |
url |
https://www.banglajol.info/index.php/BJP/article/view/12499 |
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