Optical coherence tomography angiography changes in radial peripapillary capillaries in Leber hereditary optic neuropathy

• Main Authors: Mitsuhiro Matsuzaki, Yasuhiko Hirami, Hirofumi Uyama, Yasuo Kurimoto
• Format: Article
• Language: English
• Published: Elsevier 2018-03-01
• Series: American Journal of Ophthalmology Case Reports
• Subjects: Leber hereditary optic neuropathy; Optical coherence tomography angiography; Optical coherence tomography; Radial peripapillary capillary; Retinal full thickness; Peripapillary retinal nerve fiber layer
• Online Access: http://www.sciencedirect.com/science/article/pii/S2451993617301809

Purpose: To present a report of longitudinal changes in radial peripapillary capillaries (RPC) and changes in retinal full thickness (RFT) and peripapillary retinal nerve fiber layer (RNFL) in a patient with Leber hereditary optic neuropathy (LHON). Observations: A 42-year-old man presented with acute- and presymptomatic-stage LHON in the left (OS) and right (OD) eyes, respectively, at the initial visit. Onset of LHON in the OD was observed 2 months after the initial visit. Once the temporal RNFL started to decrease in thickness, the areas of temporal RPC defects and RFT thinning gradually increased, indicating that these factors might be correlated. Conclusions and importance: Optical coherence tomography angiography showed LHON from the presymptomatic stage. The results indicate that temporal RPC defects and RFT thinning start to spread once the pseudoedema begins to resolve.