Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders
Abstract Background During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known as hepatokines, play important roles in lipid metabolism. The purposes...
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doaj-30696256a07542ba9751e3cce55986012020-11-25T02:39:31ZengBMCBMC Veterinary Research1746-61482018-08-011411910.1186/s12917-018-1560-7Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disordersJianguo Wang0Xiaoyan Zhu1Guanghui She2Yezi Kong3Yazhou Guo4Zhe Wang5Guowen Liu6Baoyu Zhao7College of Veterinary Medicine, Northwest A&F UniversityCollege of Veterinary Medicine, Northwest A&F UniversityCollege of Veterinary Medicine, Northwest A&F UniversityCollege of Veterinary Medicine, Northwest A&F UniversityCollege of Veterinary Medicine, Northwest A&F UniversityCollege of Veterinary Medicine, Jilin UniversityCollege of Veterinary Medicine, Jilin UniversityCollege of Veterinary Medicine, Northwest A&F UniversityAbstract Background During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known as hepatokines, play important roles in lipid metabolism. The purposes of our study were to evaluate variations of serum ANGPTL4 and FGF21 concentrations in periparturient dairy cows and changes in these serum analyte concentrations of energy-related metabolic disorders in early lactation dairy cows. This study was divided into two experiments. Experiment I: Blood parameters were measured in healthy periparturient Holstein cows from 4 wk antepartum to 4 wk postpartum (n = 219). In this experiment, weekly blood samples were obtained from 4 wk before the expected calving date through 4 wk after calving. Experiment II: Blood parameters were measured in healthy cows (n = 30) and cows with clinical ketosis (n = 29) and fatty liver (n = 25) within the first 4 wk of lactation. In the present study, all blood samples were collected from the coccygeal vein in the early morning before feeding. Results Serum ANGPTL4 and FGF21 concentrations peaked at parturition, and declined rapidly over the following 2 wk Serum ANGPTL4 and FGF21 concentrations were positively correlated with serum non-esterified fatty acids (NEFA) concentration (r = 0.856, P = 003; r = 0.848, P = 0.004, respectively). Cows with clinical ketosis and fatty liver had significantly higher serum ANGPTL4 and FGF21 concentrations than healthy cows (P < 0.01). Conclusion Serum ANGPTL4 and FGF21 concentrations were elevated during peripartum period, suggesting that energy balance changes that were associated with parturition contributed significantly to these effects. Although FGF21 and ANGPTL4 could play important roles in the adaptation of energy metabolism, they may be involved in the pathological processes of energy metabolism disorders of dairy cows in the peripartum period.http://link.springer.com/article/10.1186/s12917-018-1560-7Dairy cowPeripartum periodAngiopoietin-like protein 4Fibroblast growth factor 21Energy metabolism disorder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jianguo Wang Xiaoyan Zhu Guanghui She Yezi Kong Yazhou Guo Zhe Wang Guowen Liu Baoyu Zhao |
spellingShingle |
Jianguo Wang Xiaoyan Zhu Guanghui She Yezi Kong Yazhou Guo Zhe Wang Guowen Liu Baoyu Zhao Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders BMC Veterinary Research Dairy cow Peripartum period Angiopoietin-like protein 4 Fibroblast growth factor 21 Energy metabolism disorder |
author_facet |
Jianguo Wang Xiaoyan Zhu Guanghui She Yezi Kong Yazhou Guo Zhe Wang Guowen Liu Baoyu Zhao |
author_sort |
Jianguo Wang |
title |
Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders |
title_short |
Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders |
title_full |
Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders |
title_fullStr |
Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders |
title_full_unstemmed |
Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders |
title_sort |
serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders |
publisher |
BMC |
series |
BMC Veterinary Research |
issn |
1746-6148 |
publishDate |
2018-08-01 |
description |
Abstract Background During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known as hepatokines, play important roles in lipid metabolism. The purposes of our study were to evaluate variations of serum ANGPTL4 and FGF21 concentrations in periparturient dairy cows and changes in these serum analyte concentrations of energy-related metabolic disorders in early lactation dairy cows. This study was divided into two experiments. Experiment I: Blood parameters were measured in healthy periparturient Holstein cows from 4 wk antepartum to 4 wk postpartum (n = 219). In this experiment, weekly blood samples were obtained from 4 wk before the expected calving date through 4 wk after calving. Experiment II: Blood parameters were measured in healthy cows (n = 30) and cows with clinical ketosis (n = 29) and fatty liver (n = 25) within the first 4 wk of lactation. In the present study, all blood samples were collected from the coccygeal vein in the early morning before feeding. Results Serum ANGPTL4 and FGF21 concentrations peaked at parturition, and declined rapidly over the following 2 wk Serum ANGPTL4 and FGF21 concentrations were positively correlated with serum non-esterified fatty acids (NEFA) concentration (r = 0.856, P = 003; r = 0.848, P = 0.004, respectively). Cows with clinical ketosis and fatty liver had significantly higher serum ANGPTL4 and FGF21 concentrations than healthy cows (P < 0.01). Conclusion Serum ANGPTL4 and FGF21 concentrations were elevated during peripartum period, suggesting that energy balance changes that were associated with parturition contributed significantly to these effects. Although FGF21 and ANGPTL4 could play important roles in the adaptation of energy metabolism, they may be involved in the pathological processes of energy metabolism disorders of dairy cows in the peripartum period. |
topic |
Dairy cow Peripartum period Angiopoietin-like protein 4 Fibroblast growth factor 21 Energy metabolism disorder |
url |
http://link.springer.com/article/10.1186/s12917-018-1560-7 |
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