Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA
DYT1 dystonia, a common and severe primary dystonia, is caused by a 3-bp deletion in TOR1A which encodes torsinA, a protein found in the endoplasmic reticulum. Several cellular functions are altered by the mutant protein, but at a systems level the link between these and the symptoms of the disease...
Main Authors: | Giuseppe Sciamanna, Robert Hollis, Chelsea Ball, Giuseppina Martella, Annalisa Tassone, Andrea Marshall, Dee Parsons, Xinru Li, Fumiaki Yokoi, Lin Zhang, Yuqing Li, Antonio Pisani, David G. Standaert |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2012-09-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996112001611 |
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