Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer
Abstract Background Early prediction of tumor response to neoadjuvant chemotherapy (NACT) is crucial for optimal treatment and improved outcome in breast cancer patients. The purpose of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to NACT in...
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doaj-3072cfeae95947c2bc0c81140888d6512021-05-02T11:30:54ZengBMCBreast Cancer Research1465-542X2021-04-0123111310.1186/s13058-021-01429-4Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancerJuanjuan Gu0Eric C. Polley1Max Denis2Jodi M. Carter3Sandhya Pruthi4Adriana V. Gregory5Judy C. Boughey6Robert T. Fazzio7Mostafa Fatemi8Azra Alizad9Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and ScienceDepartment of Health Science, Mayo Clinic College of Medicine and ScienceDepartment of Radiology, Mayo Clinic College of Medicine and ScienceDepartment of Laboratory Medicine & Pathology, Mayo Clinic College of Medicine and ScienceDepartment of Medicine, Mayo Clinic College of Medicine and ScienceDepartment of Radiology, Mayo Clinic College of Medicine and ScienceDepartment of Surgery, Mayo Clinic College of Medicine and ScienceDepartment of Radiology, Mayo Clinic College of Medicine and ScienceDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and ScienceDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and ScienceAbstract Background Early prediction of tumor response to neoadjuvant chemotherapy (NACT) is crucial for optimal treatment and improved outcome in breast cancer patients. The purpose of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to NACT in patients with invasive breast cancer. Methods In a prospective study, 62 patients with biopsy-proven invasive breast cancer were enrolled. Three SWE studies were conducted on each patient: before, at mid-course, and after NACT but before surgery. A new parameter, mass characteristic frequency (f mass), along with SWE measurements and mass size was obtained from each SWE study visit. The clinical biomarkers were acquired from the pre-NACT core-needle biopsy. The efficacy of different models, generated with the leave-one-out cross-validation, in predicting response to NACT was shown by the area under the receiver operating characteristic curve and the corresponding sensitivity and specificity. Results A significant difference was found for SWE parameters measured before, at mid-course, and after NACT between the responders and non-responders. The combination of E mean2 and mass size (s 2) gave an AUC of 0.75 (0.95 CI 0.62–0.88). For the ER+ tumors, the combination of E mean_ratio1, s 1, and Ki-67 index gave an improved AUC of 0.84 (0.95 CI 0.65–0.96). For responders, f mass was significantly higher during the third visit. Conclusions Our study findings highlight the value of SWE estimation in the mid-course of NACT for the early prediction of treatment response. For ER+ tumors, the addition of Ki-67improves the predictive power of SWE. Moreover, f mass is presented as a new marker in predicting the endpoint of NACT in responders.https://doi.org/10.1186/s13058-021-01429-4Immunohistochemical biomarkersKi-67Shear wave elastographyNeoadjuvant chemotherapyBreast cancerMass characteristic frequency |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juanjuan Gu Eric C. Polley Max Denis Jodi M. Carter Sandhya Pruthi Adriana V. Gregory Judy C. Boughey Robert T. Fazzio Mostafa Fatemi Azra Alizad |
spellingShingle |
Juanjuan Gu Eric C. Polley Max Denis Jodi M. Carter Sandhya Pruthi Adriana V. Gregory Judy C. Boughey Robert T. Fazzio Mostafa Fatemi Azra Alizad Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer Breast Cancer Research Immunohistochemical biomarkers Ki-67 Shear wave elastography Neoadjuvant chemotherapy Breast cancer Mass characteristic frequency |
author_facet |
Juanjuan Gu Eric C. Polley Max Denis Jodi M. Carter Sandhya Pruthi Adriana V. Gregory Judy C. Boughey Robert T. Fazzio Mostafa Fatemi Azra Alizad |
author_sort |
Juanjuan Gu |
title |
Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer |
title_short |
Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer |
title_full |
Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer |
title_fullStr |
Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer |
title_full_unstemmed |
Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer |
title_sort |
early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer |
publisher |
BMC |
series |
Breast Cancer Research |
issn |
1465-542X |
publishDate |
2021-04-01 |
description |
Abstract Background Early prediction of tumor response to neoadjuvant chemotherapy (NACT) is crucial for optimal treatment and improved outcome in breast cancer patients. The purpose of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to NACT in patients with invasive breast cancer. Methods In a prospective study, 62 patients with biopsy-proven invasive breast cancer were enrolled. Three SWE studies were conducted on each patient: before, at mid-course, and after NACT but before surgery. A new parameter, mass characteristic frequency (f mass), along with SWE measurements and mass size was obtained from each SWE study visit. The clinical biomarkers were acquired from the pre-NACT core-needle biopsy. The efficacy of different models, generated with the leave-one-out cross-validation, in predicting response to NACT was shown by the area under the receiver operating characteristic curve and the corresponding sensitivity and specificity. Results A significant difference was found for SWE parameters measured before, at mid-course, and after NACT between the responders and non-responders. The combination of E mean2 and mass size (s 2) gave an AUC of 0.75 (0.95 CI 0.62–0.88). For the ER+ tumors, the combination of E mean_ratio1, s 1, and Ki-67 index gave an improved AUC of 0.84 (0.95 CI 0.65–0.96). For responders, f mass was significantly higher during the third visit. Conclusions Our study findings highlight the value of SWE estimation in the mid-course of NACT for the early prediction of treatment response. For ER+ tumors, the addition of Ki-67improves the predictive power of SWE. Moreover, f mass is presented as a new marker in predicting the endpoint of NACT in responders. |
topic |
Immunohistochemical biomarkers Ki-67 Shear wave elastography Neoadjuvant chemotherapy Breast cancer Mass characteristic frequency |
url |
https://doi.org/10.1186/s13058-021-01429-4 |
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