Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells.

Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells.

OBJECTIVE: Trastuzumab has been used for the treatment of HER2-positive breast cancer (BC). However, a subset of BC patients exhibited resistance to trastuzumab therapy. Thus, clarifying the molecular mechanism of trastuzumab treatment will be beneficial to improve the treatment of HER2-positive BC...

Full description

Bibliographic Details
Main Authors:	Takehiro Ichikawa, Fumiaki Sato, Kazuya Terasawa, Soken Tsuchiya, Masakazu Toi, Gozoh Tsujimoto, Kazuharu Shimizu
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3288043?pdf=render

Similar Items

Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers
by: Kazuya Terasawa, et al.
Published: (2011-01-01)

The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation
by: Cláudia Regina Gasque Schoof, et al.
Published: (2015-01-01)

Association study of relationships of polymorphisms in the miR-21, miR-26b, miR-221/222 and miR-126 genes with cervical intraepithelial neoplasia and cervical cancer
by: Jia Yang, et al.
Published: (2021-09-01)

Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients
by: Qiu Shuwei, et al.
Published: (2013-01-01)

Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer
by: Schee Kristina, et al.
Published: (2012-11-01)

Simultaneous downregulation of miR-21 and upregulation of miR-7 has anti-tumor efficacy
by: Deepak Bhere, et al.
Published: (2020-02-01)

Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma.
by: Sven H Loosen, et al.
Published: (2019-01-01)

Decreased expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4⁺ T cells and peripheral blood from tuberculosis patients.
by: Katja Kleinsteuber, et al.
Published: (2013-01-01)

Elevated Serum miR-7, miR-9, miR-122, and miR-141 Are Noninvasive Biomarkers of Acute Pancreatitis
by: Pan Lu, et al.
Published: (2017-01-01)

The role of the miR-26 family in neurogenesis
by: Ziegenhals, Thomas
Published: (2018)

MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression.
by: Kristoffer Unterbruner, et al.
Published: (2018-01-01)

Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R.
by: Lulu Farhana, et al.
Published: (2013-01-01)

Circulating miR-26a-1, miR-146a and miR-199a-1 are potential candidate biomarkers for acute myocardial infarction
by: Sheng Xue, et al.
Published: (2019-05-01)

FAIM Is Regulated by MiR-206, MiR-1-3p and MiR-133b
by: Elena Coccia, et al.
Published: (2020-12-01)

Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224
by: Parisa Naeli, et al.
Published: (2017-11-01)

Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells.
by: Oshrat Hershkovitz Rokah, et al.
Published: (2012-01-01)

Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors
by: Abbas Mosapour, et al.
Published: (2020-08-01)

Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, Identify Cirrhotic Patients with HCC.
by: Francesca Fornari, et al.
Published: (2015-01-01)

Upregulation of miR181a/miR212 Improves Myogenic Commitment in Murine Fusion-Negative Rhabdomyosarcoma
by: Enrico Pozzo, et al.
Published: (2021-08-01)

MiR-26a/miR-26b represses tongue squamous cell carcinoma progression by targeting PAK1
by: Zhenxing Wei, et al.
Published: (2020-03-01)

Methylation of <it>miR-34a, miR-34b/c</it>, <it>miR-124-1 </it>and <it>miR-203 </it>in Ph-negative myeloproliferative neoplasms
by: Chim Chor Sang, et al.
Published: (2011-11-01)

Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis
by: Ferah Budak, et al.
Published: (2016-01-01)

Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle
by: Uney James B, et al.
Published: (2011-06-01)

Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma.
by: Xi Zeng, et al.
Published: (2012-01-01)

Expression of miR-127, miR-154, and miR-183 in Medullary Thy-roid Carcinoma Tumors
by: Mahsa RAHMANI SAMANI, et al.
Published: (2021-02-01)

Identification of putative target genes of miR-106b, miR-93, miR-25 in medulloblastoma.
Published: (2011)

Intra-platform repeatability and inter-platform comparability of microRNA microarray technology.
by: Fumiaki Sato, et al.
Published: (2009-01-01)

Natalizumab Therapy Modulates miR-155, miR-26a and Proinflammatory Cytokine Expression in MS Patients.
by: Giuseppe Mameli, et al.
Published: (2016-01-01)

MiR-21, miR-34a, miR-125b, miR-181d and miR-648 levels inversely correlate with MGMT and TP53 expression in primary glioblastoma patients
by: Dorota Jesionek-Kupnicka, et al.
Published: (2017-07-01)

miR-126 and miR-126*: New Players in Cancer
by: Jeannette Meister, et al.
Published: (2010-01-01)

Role of miR-503 and miR-144 in Distraction Osteogenesis
Published: (2016)

Associations between microRNA (miR-25, miR-32, miR-125, and miR-222) polymorphisms and recurrent implantation failure in Korean women
by: Jeong Yong Lee, et al.
Published: (2019-12-01)

Assessment of miR-98-5p, miR-152-3p, miR-326 and miR-4289 Expression as Biomarker for Prostate Cancer Diagnosis
by: Leire Moya, et al.
Published: (2019-03-01)

miR-9, miR-21, miR-27b, and miR-34a Expression in HPV16/58/52-Infected Cervical Cancer
by: Mi Liu, et al.
Published: (2020-01-01)

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis
by: Yanhua Wu, et al.
Published: (2017-01-01)

Diagnostic and Prognostic Value of miR-16, miR-146a, miR-192 and miR-221 in Exosomes of Hepatocellular Carcinoma and Liver Cirrhosis Patients
by: Thorben Fründt, et al.
Published: (2021-05-01)

Upregulation of miR-133b and miR-328 in Patients With Atrial Dilatation: Implications for Stretch-Induced Atrial Fibrillation
by: Michela Masè, et al.
Published: (2019-09-01)

Mir-1, miR-122, miR-132, and miR-133 Are Related to Subclinical Aortic Atherosclerosis Associated with Metabolic Syndrome
by: Agnė Šatrauskienė, et al.
Published: (2021-02-01)

Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model
by: Ricardo Brianezi Tiraboschi, MD, PhD, et al.
Published: (2021-04-01)

Alterations in the Expression Profile of Serum miR-155, miR-223, miR-17, miR-200a, miR-205, as well as Levels of Interleukin 6, and Prostaglandins during Endometritis in Arabian Mares
by: Sally Ibrahim, et al.
Published: (2021-06-01)